DEMETHOXYCURCUMIN

Bezeichnung:DEMETHOXYCURCUMIN

CAS-Nr22608-11-3

Englisch Name:DEMETHOXYCURCUMIN

CBNumberCB0960423

SummenformelC20H18O5

Molgewicht338.35

MOL-Datei22608-11-3.mol

DEMETHOXYCURCUMIN physikalisch-chemischer Eigenschaften

Schmelzpunkt	166～170℃
Siedepunkt	571.4±50.0 °C(Predicted)
Dichte	1.282±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: ≥10mg/mL
pka	8.31±0.46(Predicted)
Aggregatzustand	powder
Farbe	orange
LogP	3.113 (est)

Sicherheit

Kennzeichnung gefährlicher	N
R-Sätze:	50
S-Sätze:	61
RIDADR	UN 3077 9 / PGIII
WGK Germany	2
HS Code	29145090

Gefahreninformationscode (GHS)

DEMETHOXYCURCUMIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
The demethoxy derivative of Curcumin (C838500) that regulates anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. It attenuates the Wnt/β-catenin pathway through do wn-regulation of the transcriptional coactivator p300.
Verwenden
Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin. More stable than curcumin in physiological media, DMC suppresses proliferation in cancer cells at 50-100 μM. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits lipopolysaccharide induction of iNOS.
Definition
ChEBI: Demethoxycurcumin is a beta-diketone that is curcumin in which one of the methoxy groups is replaced by hydrogen. It is found in Curcuma zedoaria and Etlingera elatior. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent. It is a polyphenol, a beta-diketone, an enone and a diarylheptanoid.
Allgemeine Beschreibung
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biochem/physiol Actions
Demethoxycurcumin (DMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. DMC inhibits LPS-induced nitric oxide (NO) production, and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. DMC also inhibits NF-kB dependent iNOS, TNFα and IL-1β expression in LPS-treated rat microglial cells. DMC suppresses expression of MMPs and ICAM-1 in MDA-MB-231 human breast cancer cells by inhibition of NF-kB.

DEMETHOXYCURCUMIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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