iproniazid Struktur

4-Pyridincarbonsäure-2-(1-methyl-ethyl)hydrazid

Bezeichnung:4-Pyridincarbonsäure-2-(1-methyl-ethyl)hydrazid

CAS-Nr54-92-2

Englisch Name:iproniazid

CBNumberCB0928533

SummenformelC9H13N3O

Molgewicht179.22

MOL-Datei54-92-2.mol

Synonyma

Iproniazid

4-Pyridincarbonsäure-2-(1-methyl-ethyl)hydrazid

4-Pyridincarbonsäure-2-(1-methyl-ethyl)hydrazid physikalisch-chemischer Eigenschaften

Schmelzpunkt	112.5-113.5°
Siedepunkt	311.75°C (rough estimate)
Dichte	1.1305 (rough estimate)
Brechungsindex	1.5100 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
pka	11.28±0.23(Predicted)
Aggregatzustand	Solid
Farbe	Pale Beige
CAS Datenbank	54-92-2

Sicherheit

HS Code

2933399990

Toxizität

An isopropyl derivative of isoniazid that was found to have mood-elevating effects in tuberculosis patients. It was later found to be a monoamine oxidase (MAO) inhibitor and, although not currently approved for clinical use as an antidepressant due to its propensity to cause liver damage it led to the development of other MAO inhibitors currently in use. In addition to hepatotoxic effects, iproniazid is a hypotensive agent and can cause potentially hazardous reactions with other drugs and amine-rich foods.

Gefahreninformationscode (GHS)

iproniazid Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Marsilid,Roche,US,1952
Verwenden
Iproniazid is a hydrazine based drug used as an antidepressant. Iproniazid acts as an irreversible and nonselective monoamine oxidase inhibitor.
Definition
ChEBI: Iproniazid is a carbohydrazide and a member of pyridines.
Manufacturing Process
A mixture of 40 g of isonicotinyl hydrazine and 600 cc of acetone was heated on a steam bath until solution was complete. Upon cooling the reaction mixture, 1-isonicotinyl-2-isopropylidene hydrazine precipitated in the form of white needles; MP 161°C to 161.5°C.
A solution of 20 g of 1-isonicotinyl-2-isopropylidene hydrazine in 150 cc of methanol was reduced with hydrogen at room temperature and 50 psi using 300 mg of platinum black as a catalyst.
Trademarks
Euphozid;Ipropran;Isotamine;Laniazid;Marsilid;Nydrazid;P-1-n forte;Pms isoniazid;Rifamate;Rimactane;Rimifon;Ro 7-1554;Teebaconin;Triniad;Uniad.
Therapeutic Function
Antidepressant, Monoamine oxidase inhibitor
Weltgesundheitsorganisation (WHO)
Iproniazid, a monoamine oxidase inhibitor (MAOI), was introduced in 1952 for the treatment of depressive illness. Subsequently concern regarding potentially serious interactions between MAOIs and foods containing tyramine inspired much restrictive regulatory action. However, MAOIs still retain a place in the treatment of serious depressive illness although there is no international consensus on which compounds should be preferred. Thus iproniazid remains available in several countries.
läuterung methode
Crystallise it from *benzene or *benzene /pet ether and dry it in a vacuum. It is soluble in H2O and EtOH. [Fox & Gibas J Org Chem 18 994 1953.] The dihydrochloride has m 227-228o (from EtOH). [Beilstein 22 III/IV 551.] It is an antidepressant.

iproniazid Upstream-Materialien And Downstream Produkte

4-Pyridincarbonsäure-2-(1-methyl-ethyl)hydrazid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

54-92-2, iproniazid Verwandte Suche:

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