5-Brom-1,10-phenanthrolin

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H318：Verursacht schwere Augenschäden.

• Sicherheit

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P310：Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen.

  P330：Mund ausspülen.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

5-bromo-1,10-phenanthroline Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  5-bromo-1,10-phenanthroline can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

• Synthese

  
  The compound was synthesized using a modification of the preparation described by Mlochowski.35 The yield of product is quite sensitive to the amount of bromine employed, the temperature, and the reaction time. Higher temperatures result in the formation of varying amounts of 5,6-dibromophenanthroline and 1,10-phenanthroline-5,6-dione. In our hands, the following preparation resulted in the maximum yield of product. A 3.6 g (20 mmol) sample of phenanthroline was placed in a heavy-walled glass reaction tube with a Teflon screw top fitted with a Viton O-ring. The reaction vessel was placed in an ice bath, and 12 mL of oleum (15%) and 0.60 mL (11.6 mmol) of bromine were added. The reaction tube was placed in a silicon oil bath, and the temperature was slowly raised to 135 °C. After 23 h, the reaction mixture was cooled to room temperature, poured over ice, and neutralized with NH4OH. The mixture was extracted with CHCl3. The extracts were stirred with charcoal and then dried over Na2SO4. The crude reaction mixture contained about 5% unreacted phenanthroline as judged by 1H NMR spectroscopy. The solid was recrystallized from hot diethyl ether with a minimum amount of CH2Cl2. Yield 4.67 g (90%).

5-bromo-1,10-phenanthroline Upstream-Materialien And Downstream Produkte

5-Brom-1,10-phenanthrolin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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