Phenyl-4-aminosalicylate Struktur

Fenamisal

Bezeichnung:Fenamisal

CAS-Nr133-11-9

Englisch Name:Phenyl-4-aminosalicylate

CBNumberCB0734217

SummenformelC13H11NO3

Molgewicht229.23

MOL-Datei133-11-9.mol

Synonyma

Fenamisal

Fenamisal physikalisch-chemischer Eigenschaften

Schmelzpunkt	150-152 °C(lit.)
Siedepunkt	371.13°C (rough estimate)
Dichte	1.2084 (rough estimate)
Brechungsindex	1.5500 (estimate)
storage temp.	-20°C Freezer
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
pka	8.76±0.10(Predicted)
Aggregatzustand	Solid
Farbe	Off-White
CAS Datenbank	133-11-9(CAS DataBase Reference)
EPA chemische Informationen	Phenyl 4-aminosalicylate (133-11-9)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3

Gefahreninformationscode (GHS)

Phenyl-4-aminosalicylate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
WHITE POWDER
Originator
Pheny-Pas-Teb-Amin ,Purdue Frederick, US,1959
Verwenden
Antibacterial(tuberculostatic).
Verwenden
Phenyl 4-Aminosalicylate is a reactant in the synthesis of p-aminosalicylic ester imines with antitubercular activity.
Definition
ChEBI: 4-amino-2-hydroxybenzoic acid phenyl ester is a carbonyl compound.
Manufacturing Process
183 g of p-nitrosalicylic acid are dissolved in 564 g of phenol by heating to 140°C to 150°C on an oil bath. When all the p-nitrosalicylic acid is dissolved, 153 g of phosphorus oxychloride are run in, drop by drop, over a period of about 2 hours, while maintaining the temperature at about 150°C. The still warm mixture is run into 2 liters of water with agitation. The precipitate formed is filtered off, washed with water until phenol is removed and then dried.
There are thus obtained 250 g of 2-hydroxy-4-nitrophenylbenzoate which melts at 154°C to 155°C.
In a hydrogenation autoclave are introduced 92 g of 2-hydroxy-4nitrophenylbenzoate preceded by 200 cc of ethyl acetate; Raney nickel, obtained from 30 g of alloy, is added with 300 cc of ethyl acetate. Hydrogenation under pressure (100 to 120 kg) at ordinary temperature is carried out during a period of about 12 hours. The nickel is filtered off and the ethyl acetate is removed by distillation on the water bath under a vacuum of 300 mm. There is thus obtained 80 g of crude damp 2-hydroxy-4amnophenylbenzoate which after recrystallization from isopropyl alcohol melts at 153°C.
Trademarks
Pheny-Pas-Tebamin (Purdue Frederick).
Therapeutic Function
Antibacterial (tuberculostatic)
läuterung methode
Crystallise the ester from EtOH (m 155o, also 149-150.5o), aqueous EtOH (m 147-149o), or isopropanol. It is tuberculostatic.[Beilstein 13 IV 1979.]

Phenyl-4-aminosalicylate Upstream-Materialien And Downstream Produkte

Fenamisal Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

133-11-9, Phenyl-4-aminosalicylate Verwandte Suche:

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