cis-4-Hydroxycyclohexanecarboxylic acid Struktur

cis-4-Hydroxycyclohexanecarboxylic acid

Bezeichnung:cis-4-Hydroxycyclohexanecarboxylic acid

CAS-Nr3685-22-1

Englisch Name:cis-4-Hydroxycyclohexanecarboxylic acid

CBNumberCB0727376

SummenformelC7H12O3

Molgewicht144.17

MOL-Datei3685-22-1.mol

cis-4-Hydroxycyclohexanecarboxylic acid physikalisch-chemischer Eigenschaften

Schmelzpunkt	150°C
Siedepunkt	115 °C(Press: 8 Torr)
Dichte	1.246
storage temp.	2-8°C
Löslichkeit	almost transparency in Methanol
Aggregatzustand	powder to crystal
pka	pK1:4.836 (25°C)
Farbe	White to Almost white
InChI	InChI=1S/C7H12O3/c8-6-3-1-5(2-4-6)7(9)10/h5-6,8H,1-4H2,(H,9,10)/t5-,6+
InChIKey	HCFRWBBJISAZNK-OLQVQODUSA-N
SMILES	[C@@H]1(C(O)=O)CC[C@H](O)CC1
CAS Datenbank	3685-22-1

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	36/37/38-25
S-Sätze:	26-36/37/39-45
RIDADR	UN 2811 6.1 / PGIII
HS Code	2918199890

Gefahreninformationscode (GHS)

cis-4-Hydroxycyclohexanecarboxylic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
White to Almost white powder to crystal. Melting point: 148.0 to 152.0 °C.
Verwenden
Cis-4-Hydroxycyclohexanecarboxylic acid is a metabolite of p-hydroxybenzoic acid. It is the major metabolite in the urine of rats treated with exogenous p-hydroxybenzoic acid. It has been found to have immunosuppressive activities in rat hepatocytes, as well as metabolic disorders that are related to hyperglycemia or diabetes mellitus.
Definition
ChEBI: 4-Hydroxycyclohexylcarboxylic acid is a hydroxy monocarboxylic acid.
Synthese
cis-4-Hydroxycyclohexanecarboxylic acid can be synthesized through the following steps:
1. In an argon glove box, dissolve ligands L1-(S,R)-f-ambinol (7.5mg, 0.0105mmol) and [Ir(COD)Cl]2 (3.4mg, 0.005mmol) in 1 mL of iPrOH in a 2mL vial and stir at room temperature for 2 h.
2. Put 1 mmol of raw material 4-substituted cyclohexanone into a 4 mL hydrogenation flask.
3. Add 0.1 mL of the in-situ complexed catalyst solution and 1.6 mg of tBuOLi solid powder to the hydrogenation flask.
4. Add 1 mL of EtOH to dissolve the reactants in the hydrogenation flask.
5. Put the reaction flask into the hydrogenation kettle and replace the kettle body with hydrogen three times.
6. Fill the kettle with 5bar H2 and react at room temperature for 12h.
7. After the reaction is completed, carefully release the hydrogen and spin-dry the solvent under reduced pressure.
8. Purify the hydrogenated product cis-4-substituted cyclohexanol by silica gel column.
9. Obtain the final product cis-4-Hydroxycyclohexanecarboxylic acid.

cis-4-Hydroxycyclohexanecarboxylic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

3685-22-1, cis-4-Hydroxycyclohexanecarboxylic acid Verwandte Suche:

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