N-ACETYL-4-BENZOQUINONE IMINE

Bezeichnung:N-ACETYL-4-BENZOQUINONE IMINE

CAS-Nr50700-49-7

Englisch Name:N-ACETYL-4-BENZOQUINONE IMINE

CBNumberCB0696629

SummenformelC8H7NO2

Molgewicht149.15

MOL-Datei50700-49-7.mol

N-ACETYL-4-BENZOQUINONE IMINE physikalisch-chemischer Eigenschaften

Schmelzpunkt	74-75
Siedepunkt	255.6±43.0 °C(Predicted)
Dichte	1.13±0.1 g/cm3(Predicted)
storage temp.	-70°C
Löslichkeit	Chloroform (Slightly, Sonicated), DMSO (Slightly)
Aggregatzustand	Solid
pka	-3.37±0.20(Predicted)
Farbe	Pale Yellow to Very Dark Red
Stabilität	Temperature, Moisture, Light, and Oxygen Sensitive
CAS Datenbank	50700-49-7

Sicherheit

WGK Germany	3
RTECS-Nr.	AC6960000
HS Code	2902110000
Toxizität	LD50 i.p. in male BALB/c mice: 20 mg/kg (Dahlin, Nelson)

Gefahreninformationscode (GHS)

N-ACETYL-4-BENZOQUINONE IMINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis.
Chemische Eigenschaften
Yellow Crystalline Solid
Verwenden
Reactant involved in:• ;Redox reactions1• ;Hydrohalogenation2• ;pH dependent reactions: in acidic media it is hydrolyzed, hydroxylated in alkaline media, and dimerized at intermediate pHs3• ;Mediation of acetaminophen hepatotoxicity4• ;Studies to identify the utility of acetaminophen for treating autoimmune disorders5
Verwenden
A toxic metabolite of Acetaminophen (A161220), which reacts with serum proteins.
Verwenden
A toxic metabolite of Acetaminophen, which reacts with serum proteins
Verwenden
N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis.
Definition
ChEBI: N-acetyl-1,4-benzoquinone imine is a quinone imine and a ketoimine. It is functionally related to a 1,4-benzoquinone imine.

N-ACETYL-4-BENZOQUINONE IMINE Upstream-Materialien And Downstream Produkte

N-ACETYL-4-BENZOQUINONE IMINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

50700-49-7, N-ACETYL-4-BENZOQUINONE IMINE Verwandte Suche:

Send Inquriy