Doripenem hydrate

Bezeichnung:Doripenem hydrate

CAS-Nr364622-82-2

Englisch Name:Doripenem hydrate

CBNumberCB0511313

SummenformelC15H26N4O7S2

Molgewicht438.51

MOL-Datei364622-82-2.mol

Doripenem hydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	173°C(dec.)(lit.)
storage temp.	2-8°C
Löslichkeit	H2O: soluble5mg/mL, clear (warmed)
Aggregatzustand	powder
Farbe	white to beige
PH	Dissolve 0.3g of Doripenem Hydrate in 30mL of water: the pH of the solution is between 4.5 and 6.0.
BRN	15340136
InChIKey	NTUBEBXBDGKBTJ-WGLOMNHJSA-N
CAS Datenbank	364622-82-2(CAS DataBase Reference)

Sicherheit

WGK Germany	3
HS Code	2935.90.9500

Gefahreninformationscode (GHS)

Doripenem hydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Doripenem hydrate is a carbapenem derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of infections such as HOSPITAL-ACQUIRED PNEUMONIA, and complicated intra-abdominal or urinary-tract infections, including PYELONEPHRITIS.
Doripenem hydrate was first approved by Pharmaceuticals and Medical Devices Agency of Japan (PMDA) on July 25, 2005, then approved by the U.S. Food and Drug Administration (FDA) on Oct 12, 2007, and approved by European Medicines Agency (EMA) on July 25, 2008. It was developed by Shionogi and Janssen, then marketed as Finibax® in Japan and as Doribax® in the US by Shionogi and as Doribax® by Janssen in BE.
Chemische Eigenschaften
Doripenem Hydrate occurs as a white to pale yellow-brown-white crystalline powder. It is sparingly soluble in water, slightly soluble in methanol, and practically insoluble in ethanol (99.5). It is gradually colored to pale yellow-brown-white by light.
Verwenden
Doripenem (doripenem monohydrate) is an ultra-broad spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It is particularly active against Pseudomonas aeruginosa
Verwenden
Doripenem monohydrate is a broad spectrum antibiotic belonging to the class of antibiotics called carbapenems.
Application
Doripenem monohydrate can be used as the precursor for the preparation of doripenem which may be used as an analytical reference standard for the determination of doripenem in:
Bovine muscle by liquid chromatography combined with tandem mass spectrometry (LC-MS/MS).
Bulk drug and formulations by high performance thin layer chromatography (HPTLC).
Medicinal products by capillary electrophoresis coupled to ultraviolet (UV) detector as well as micellar electrokinetic chromatography (MEKC) with UV detection.
Definition
ChEBI: Doripenem hydrate is a member of carbapenems.
Biochem/physiol Actions
Doripenem is an ultra-broad spectrum carbopenem antibiotic. Doripenem is active against both gram-positive and gram-negative bacteria.
Mode of action
Doripenem hydrate is a β-lactam antibiotic of the carbapenem class. It is effective against extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae, a microbe resistant to many first line beta-lactam antibiotics and certain cephalosporins. Doripenem hydrate is sparingly soluble in aqueous solution.
β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP's are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases; however, carbapenems, including doripenem, are highly resistant to β-lactamases.
Einzelnachweise
[1]. yutaka nishino, makoto kobayashi, taneyoshi shinno, et al. practical large-scale synthesis of doripenem: a novel 1a-methylcarbapenem antibiotic. organic process research & development, 2003, 7:846-850.
[2]. masakatsu tsuji, yoshikazu ishii, akira ohno, et al. in vitro and in vivo antibacterial activities of s-4661, a new carbapenem. antimicrobial agents and chemotherapy, 1998, 42(1): 94-99.
[3]. yunhua chen, elizabeth garber, qiuqu zhao, et al. in vitro activity of doripenem (s-4661) against multidrug-resistant gram-negative bacilli isolated from patients with cystic fibrosis. antimicrobial agents and chemotherapy, 2005, 49(6):2510-2511.

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