2,6-Dichlorobenzylamine

Bezeichnung:2,6-Dichlorobenzylamine

CAS-Nr6575-27-5

Englisch Name:2,6-Dichlorobenzylamine

CBNumberCB0474065

SummenformelC7H7Cl2N

Molgewicht176.04

MOL-Datei6575-27-5.mol

2,6-Dichlorobenzylamine physikalisch-chemischer Eigenschaften

Schmelzpunkt	40°C
Siedepunkt	108°C/ 8mm
Dichte	1.320±0.06 g/cm3(Predicted)
Brechungsindex	1.557-1.559
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
pka	7.98±0.10(Predicted)
Aggregatzustand	Liquid
Farbe	Clear colorless to yellow
Sensitive	Air Sensitive
CAS Datenbank	6575-27-5(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	34
S-Sätze:	45-36/37/39-26
RIDADR	UN2735
HazardClass	8
PackingGroup	III
HS Code	29214990

Gefahreninformationscode (GHS)

2,6-Dichlorobenzylamine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
Clear pale yellow liquid
Verwenden
(2,6-Dichlorophenyl)methanamine was one of the reactants used in making a library of highly selective and potent G protein-coupled receptor kinase 2 inhibitors.
Synthese

25185-95-9

6575-27-5

The general procedure for the synthesis of 2,6-dichlorobenzaldehyde oxime as raw material for 2,6-dichlorobenzylamine was as follows: 2,6-dichlorobenzaldehyde oxime (0.121 g, 1 mmol) was mixed and milled with nano Fe3O4 (0.046 g, 0.2 mmol, particle size about 70 nm) in a porcelain mortar. Subsequently, ZrCl4 (0.233 g, 1 mmol) was added and the mixture continued to be ground at room temperature. The mortar was heated in an oil bath until the temperature of the reaction mixture reached 75-80 °C. After batchwise addition of NaBH3CN (0.314 g, 5 mmol), the reaction mixture was continued to be ground at 75-80 °C for 15 min. After the reaction was completed, H2O (5 mL) was added and stirred for 5 min. The mixture was extracted with EtOAc (2 x 5 mL), the organic phases were combined and dried with anhydrous Na2SO4. Evaporation of the solvent gave a pure 2,6-dichlorobenzylamine liquid in 93% yield (0.1 g, see Table 2, entry 1).
Einzelnachweise
[1] Journal of the Iranian Chemical Society, 2015, vol. 12, # 5, p. 873 - 878
[2] Journal of Medicinal Chemistry, 1984, vol. 27, # 9, p. 1111 - 1118

2,6-Dichlorobenzylamine Upstream-Materialien And Downstream Produkte

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