(R)-(+)-PROPRANOLOL Struktur

(R)-[2-Hydroxy-3-(naphthyloxy)propyl]isopropylammoniumchlorid

Bezeichnung:(R)-[2-Hydroxy-3-(naphthyloxy)propyl]isopropylammoniumchlorid

Englisch Name:(R)-(+)-PROPRANOLOL

CBNumberCB0327608

SummenformelC16H21NO2.ClH

Molgewicht295.81

Synonyma

(R)-[2-Hydroxy-3-(naphthyloxy)propyl]isopropylammoniumchlorid

(R)-[2-Hydroxy-3-(naphthyloxy)propyl]isopropylammoniumchlorid physikalisch-chemischer Eigenschaften

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	22-24/25
WGK Germany	3
HS Code	2922 19 00

Gefahreninformationscode (GHS)

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Physikalische Eigenschaften
(R)-Propranolol's solubility:ethanol: 10 mg/mLDMSO: <14.5 mg/mLH2O: 50 mg/mL (With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.)
Verwenden
The R-enantiomer of Propranolol (P831800). β?Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).
Verwenden
less active enantiomer
Biochem/physiol Actions
Less active enantiomer of propranolol.
Mechanism of action
Pronolol hydrochloride is a non-selective beta-receptor blocker that blocks beta receptors in the myocardium and has antagonistic effects on beta1 and beta2 receptors. Slow down the heart rate, inhibit cardiac contractility and conduction, reduce circulating blood volume, and reduce myocardial oxygen consumption.
Lager
Store at RT
läuterung methode
The hydrochloride is recrystallised from n-PrOH or Me2CO. It is soluble in H2O and EtOH but is insoluble in Et2O, *C6H6 or EtOAc. The racemate has m 163-164o, and the free base recrystallises from cyclohexane with m 96o. [Howe & Shanks Nature 210 1336 1966.] The S-isomer (below) is the physiologically active isomer.