UNC 0631

Bezeichnung:UNC 0631

CAS-Nr1320288-19-4

Englisch Name:UNC 0631

CBNumberCB02668659

SummenformelC37H61N7O2

Molgewicht635.93

MOL-Datei1320288-19-4.mol

UNC 0631 physikalisch-chemischer Eigenschaften

Siedepunkt	763.4±70.0 °C(Predicted)
Dichte	1.114±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
Löslichkeit	insoluble in H2O; ≥12.66 mg/mL in EtOH with ultrasonic; ≥18.35 mg/mL in DMSO with gentle warming
Aggregatzustand	solid
pka	9.34±0.70(Predicted)

Gefahreninformationscode (GHS)

UNC 0631 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
N-[1-(Cyclohexylmethyl)-4-piperidinyl]-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine, is a selective histone lysine methyltransferase (HMTase) inhibitor for G9a and GLP.
Verwenden
UNC0631 is a potent and selective inhibitor of G9a activity in vitro (IC50 = 4 nM) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC50 = 25 nM). It potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 cell line.[Cayman Chemical]
Biologische Aktivität
unc 0631 is a potent inhibitor of protein lysine methyltransferase g9a (also known as kmt1c or ehmt2) with the ic50 value of 4nm [1].unc 0631 has been revealed to inhibit the g9a in sahh-coupled with the ic50 of 4nm. besides, unc 0631 has been found to be highly potent in reducing h3k9me2 levels in mda-mb-231 cells with the icw ic50 of 25nm. in addition, unc 0631 has been shown the high in vitro potency against g9a and improved lipophilicity. besides, unc 0631 has also been reported to have low cell toxicity in mda-mb-231 cells with the ic50 value of 2.8μm in mtt assay. in different cell lines, unc 0631 has been demonstrated to potently reduce h3k9me2 levels with the icw ic50 of 25nm, 18nm, 26nm, 24nm, 51nm, 72nm and 46nm in mda-mb-231, mcf7, pc3, 22rv1, hct116 wt, hct 116 p53 and imr90 cell lines, respectively [1].
Einzelnachweise
[1] liu f1, barsyte-lovejoy d, allali-hassani a, he y, herold jm, chen x, yates cm, frye sv, brown pj, huang j, vedadi m, arrowsmith ch, jin j.optimization of cellular activity of g9a inhibitors 7-aminoalkoxy-quinazolines. j med chem. 2011 sep 8;54( 17):6139-50.

UNC 0631 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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