MC1568

Bezeichnung:MC1568

CAS-Nr852475-26-4

Englisch Name:MC1568

CBNumberCB02517946

SummenformelC17H15FN2O3

Molgewicht314.31

MOL-Datei852475-26-4.mol

MC1568 physikalisch-chemischer Eigenschaften

Schmelzpunkt	212-215 °C(Solv: acetonitrile (75-05-8); methanol (67-56-1))
Dichte	1.21±0.1 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: ≥10mg/mL
Aggregatzustand	powder
pka	8.91±0.23(Predicted)
Farbe	orange
InChIKey	QRDAPCMJAOQZSU-KQQUZDAGSA-N
CAS Datenbank	852475-26-4

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36
S-Sätze:	26
WGK Germany	3

Gefahreninformationscode (GHS)

MC1568 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling. Class IIa HDACs, which includes HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology. MC 1568 is a selective inhibitor of class IIa HDACs, with greater than 170-fold selectivity over class I HDACs, including HDAC1. It has been used in cells (1-10 μM) and in mice to elucidate the roles of class IIa HDACs in cell proliferation and differentiation, apoptosis, myogenesis, adipogenesis, and fibrosis.
Verwenden
While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling. Class IIa HDACs, which includes HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology. MC 1568 is a selective inhibitor of class IIa HDACs, with greater than 170-fold selectivity over class I HDACs, including HDAC1. It has been used in cells (1-10 μM) and in mice to elucidate the roles of class IIa HDACs in cell proliferation and differentiation, apoptosis, myogenesis, adipogenesis, and fibrosis.[Cayman Chemical]
Verwenden
A selective class II (IIa) histone deacetylase (HDAC II) inhibitor. It exhibits tissue-selective inhibition between members of class II acetylases in vivo, particularly in skeletal muscle and the heart. It arrests myogenesis through the stabilization of myocyte enhancer factor 2D (MEF2D)-HDAC3/4 complex.
Definition
ChEBI: 3-[4-[3-(3-fluorophenyl)-3-oxoprop-1-enyl]-1-methyl-2-pyrrolyl]-N-hydroxy-2-propenamide is a carbonyl compound.
Biochem/physiol Actions
MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor.
Lager
+4°C

MC1568 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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