trans-Clomiphene Citrate

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H360：Kann die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen.

trans-Clomiphene Citrate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  trans-Clomiphene Citrate, stereoisomer of Clomiphene Citrate (C587025), a synthetic estrogen agonist-antagonist. Gonad-stimulating principle.

• Toxikologie

  The effects of the cis and trans isomers of clomiphene citrate on the uterine hexokinase activity of immature ovariectomized rats were studied in long- and short-term experiments. At a dose level of 600 μg/kg, both trans-Clomiphene Citrate and cis-Clomiphene Citrate caused a similar increase in total uterine hexokinase activity observable in 18 hr. When enzyme activity was expressed per g of the uterus (specific activity), significant increases were noted 18 hr after a single injection of trans clomiphene or after 4 daily injections of either isomer. Treatment of these animals with 170-estradiol (5 μg/kg) caused an elevation of both the specific and total hexokinase activities within 18 hr[1].

• Einzelnachweise

  [1] D L DiPietro, D A Goss, F J Sanders. “Effect of cis and trans isomers of clomiphene citrate on uterine hexokinase activity.” Endocrinology 84 6 (1969): 1404–8.

trans-Clomiphene Citrate Upstream-Materialien And Downstream Produkte

trans-Clomiphene Citrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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