Clomifendihydrogencitrat

Bezeichnung:Clomifendihydrogencitrat

CAS-Nr50-41-9

Englisch Name:Clomiphene Citrate

CBNumberCB0488051

SummenformelC32H36ClNO8

Molgewicht598.08

MOL-Datei50-41-9.mol

Synonyma

Clomifendihydrogencitrat

Clomifendihydrogencitrat physikalisch-chemischer Eigenschaften

Schmelzpunkt	116.5-118°C
storage temp.	2-8°C
Löslichkeit	Slightly soluble in water, sparingly soluble in ethanol (96 per cent).
Aggregatzustand	Solid
Farbe	White to Off-White
Wasserlöslichkeit	Slightly soluble in water, methanol, chloroform (slightly), and DMSO (10 mM). Insoluble in ether.
BCS Class	3/1
InChIKey	PYTMYKVIJXPNBD-OQKDUQJOSA-N
SMILES	N(CC)(CC)CCOC1=CC=C(/C(/C2=CC=CC=C2)=C(\Cl)/C2=CC=CC=C2)C=C1.C(O)(=O)CC(CC(O)=O)(C(O)=O)O
CAS Datenbank	50-41-9(CAS DataBase Reference)
IARC	3 (Vol. 21, Sup 7) 1987
EPA chemische Informationen	Clomiphene citrate (50-41-9)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	60-63
S-Sätze:	53-36/37-45
WGK Germany	3
RTECS-Nr.	YE0875000
HazardClass	IRRITANT
HS Code	2922190900
Toxizität	LD50 oral in rat: 5750mg/kg

Gefahreninformationscode (GHS)

Clomiphene Citrate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
White crystalline powder with a melting point range of 116.5-118°C. It has slight solubility in ethanol, chloroform, and water, but is insoluble in ether.
Originator
Clomid,Lepetit,Italy,1966
Verwenden
Clomiphene Citrate is an unducer of ovulation. It is a selective estrogen receptor modulator, which acts by inhibiting the action of estrogen on the pituitary. Clomiphene Citrate is also an activator of PKC and Gonad-stimulating principle.
Verwenden
Clomiphene is a selective estrogen receptor modulator that impairs the activation of estrogen receptors (ERs) by 17β-estradiol. It potently binds both ERα and ERβ (Ki = 0.9 and 1.2 nM, respectively). Clomiphene enhances the release of gonadotropin-releasing hormone, stimulating the release of follicle-stimulating hormone and luteinizing hormone, culminating in ovulation.
Manufacturing Process
A mixture of 20 g of 1-[p-(β-diethylaminoethoxy)phenyl]-1,2-diphenylethanol in 200 cc of ethanol containing an excess of hydrogen chloride was refluxed 3 hours. The solvent and excess hydrogen chloride were removed under vacuum, and the residue was dissolved in a mixture of ethyl acetate and methylene chloride. 1-[p-(β-diethylaminoethoxy)phenyl]-1,2-diphenylethylene hydrochloride was obtained, melting at 148° to 157°C. This hydrochloride salt was treated with N-chlorosuccinimide in dry chloroform under reflux. The product then obtained was converted to the free base and treated with citric acid. The dihydrogen citrate salt of 1-[p-(β-diethylaminoethoxy)phenyl]-1,2- diphenylchloroethylene was obtained, melting at 116.5° to 118°C.
The intermediate 1-[p-(β-diethylaminoethoxy)phenyl]-1,2-diphenylethanol was obtained by treating 4-(β-diethylaminoethoxy)benzophenone with benzylmagnesium chloride. It melted at 95° to 96°C.
Trademarks
Clomid (Sanofi Aventis); Serophene (Serono).
Therapeutic Function
Antiestrogen

Clomiphene Citrate Upstream-Materialien And Downstream Produkte

Clomifendihydrogencitrat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

50-41-9, Clomiphene Citrate Verwandte Suche:

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