Alonimide

Alonimide Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Alonimide ,ZYF Pharm Chemical

• Verwenden

  Sedativehypnotic.

• Manufacturing Process

  To a stirred mixture of 58.6 g (0.5 M) of phenyl-acetonitrile and 150 g (1.5 M) of ethyl acrylate was carefully added sodium methoxide in small increments (about 0.1 g). The exothermic reaction was controlled by ice bath cooling to keep the reaction mixture at 50°C. When further additions of sodium methoxide were no longer exothermic, the reaction mixture was stirred for one half hour more and the excess ethyl acrylate removed under reduced pressure on a steam bath. The resulting oil was added to 1.500 g of polyphosphoric acid and stirred on a steam bath for three hours. After cooling to about 50°C, 0.5 liter of chloroform was added followed by additions of crushed ice until the aqueous phase was free flowing. The chloroform layer was separated and combined with three 150 ml chloroform extracts of the aqueous layer. The organic phase was then dried over anhydrous magnesium sulfate, filtered and concentrated to a semi-solid residue.
  Recrystallization from acetone gave 2,3-dihydrospiro[naphthalene-1(4H),3'- piperidine]-2',4,6'-trione, melting point 197°-199°C.
  

• Therapeutic Function

  Sedative, Hypnotic

Alonimide Upstream-Materialien And Downstream Produkte

Alonimide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(5)Suppliers

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