SMZ/TMP Struktur

SMZ/TMP

Bezeichnung:SMZ/TMP

CAS-Nr8064-90-2

Englisch Name:SMZ/TMP

CBNumberCB01105579

SummenformelC24H29N7O6S

Molgewicht543.6

MOL-Datei8064-90-2.mol

SMZ/TMP physikalisch-chemischer Eigenschaften

storage temp.	-20°C
Löslichkeit	DMF: 10mg/mL,DMSO: 10mg/mL,DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL,Ethanol: 0.3mg/mL
Aggregatzustand	liquid
Farbe	colorless to faint yellow
BCS Class	4/4
EPA chemische Informationen	Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-, mixt. with 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine (8064-90-2)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38-43
S-Sätze:	26-36/37
WGK Germany	3
RTECS-Nr.	UV8240000
Giftige Stoffe Daten	8064-90-2(Hazardous Substances Data)
Toxizität	LD50 orally in mice: 5513 mg/kg (Yamamoto)

Gefahreninformationscode (GHS)

SMZ/TMP Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Cotrimoxazole is an antibiotic. Pseudomonas aeruginosa has a drug resistant rate of 66% in the years 2010-2013.
Weltgesundheitsorganisation (WHO)
The combination of sulfamethoxazole and trimethoprim (5:1) was introduced in 1971 for the treatment of a wide variety of bacterial infections. Its use has been associated with severe sensitivity reactions, many of which have been attributed to the sulphonamide component. Elderly people seem to be more vulnerable. The World Health Organization has no information further to the above concerning restrictive action taken on this combination.
Biologische Aktivität
Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.
Nebenwirkungen
Trimethoprim/sulfamethoxazole on a daily basis has a rapid onset of action but has rare associated side effects of bone marrow suppression and toxic epidermal necrolysis (TEN).
Nausea, vomiting, and anorexia are generally dose related. Hypersensitivity reactions (including Stevens-Johnson syndrome and hematologic reactions) occur in <5% of patients.
Dosage forms
One to two tablets a day. Trimethoprim is dosed at 200 mg/24 hours given either q.d. or b.i.d.

SMZ/TMP Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

8064-90-2, SMZ/TMP Verwandte Suche:

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