生物活性 体外研究 体内研究 [[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE 试剂级价格
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ChemicalBook  CAS数据库列表  [[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE

[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE

生物活性 体外研究 体内研究 [[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE 试剂级价格
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE,459836-30-7,结构式
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
  • CAS号:459836-30-7
  • 英文名:PEAQX TETRASODIUM HYDRATE
  • 中文名:[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
  • CBNumber:CB9830493
  • 分子式:C34H32Br2N6Na4O11P2
  • 分子量:1014.366082
  • MOL File:Mol file
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE化学性质
  • 密度 :1.639±0.06 g/cm3(Predicted)
  • 储存条件 :-20°C
  • 形态 :Solid
  • 酸度系数(pKa) :1.19±0.10(Predicted)
  • 颜色 :Light yellow to khaki

[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE性质、用途与生产工艺

  • 生物活性 PEAQX (NVP-AAM077) tetrasodium hydrate 是有效的、选择性的、口服有效的 NMDA 拮抗剂，其对 hNMDAR 1A 和 hNMDAR 2A 的 IC50 值分别为 270 nM 和 29600 nM。
  • 体外研究

    PEAQX (3 µM) produces similar caspase-3 activation, while NVP-AAM007 is approximately three-fold more potent.

  • 体内研究

    PEAQX (10-40 mg/kg) dose-dependently increased cortical caspase-3 activity following sub-chronic administration.
    PEAQX (10 and 20 mg/kg) shows enhanced locomotor activity in response to PCP challenge (4 mg/kg on PN28-35) compared to saline pretreatment (F 3, 73 =4.99).
    PEAQX (10 mg/kg, ip) antagonizes the effects of PRE084 on CaMKIV-TORC1-CREB and BDNF, even for learning and memory impairment.

    Animal Model: Timed, day 14 pregnant female Sprague-Dawley rats.
    Dosage: 10, 20 or 40 mg/kg.
    Administration: S.C.
    Result: Showed a sensitized locomotor response to PCP challenge on PN28-35.
    Animal Model: Timed, day 14 pregnant female Sprague-Dawley rats.
    Dosage: 4 mg/kg.
    Administration: I.P.
    Result: Did not significantly increase locomotor activity in rats treated sub-chronically with PEAQX on PN7, 9 and 11.
    Animal Model: 11-week old C57BL/6 mice.
    Dosage: 10 mg/kg.
    Administration: IP.
    Result: Reversed the effect of PRE084 (F 3,78 = 10.446, p<0.01).
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE上下游产品信息
上游原料
下游产品
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE 试剂级价格
  • 更新日期：2024/11/08
  • 产品编号：HY-12294A
  • 产品名称：PEAQX tetrasodium hydrate
  • CAS编号：
  • 包装：1 mg
  • 价格：545元
  • 更新日期：2024/11/08
  • 产品编号：HY-12294A
  • 产品名称：[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE PEAQX tetrasodium hydrate
  • CAS编号：459836-30-7
  • 包装：5mg
  • 价格：1200元
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE生产厂家
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