1-(3-氯苯胺基)-4-苯基酞嗪
- CAS号:78351-75-4
- 英文名:MY-5445
- 中文名:1-(3-氯苯胺基)-4-苯基酞嗪
- CBNumber:CB9739543
- 分子式:C20H14ClN3
- 分子量:331.8
- MOL File:78351-75-4.mol
- 沸点 :539.7±50.0 °C(Predicted)
- 密度 :1.310±0.06 g/cm3(Predicted)
- 储存条件 :Store at RT
- 溶解度 :DMF: 2 mg/ml; DMSO: 2 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
- 酸度系数(pKa) :4.91±0.30(Predicted)
- 形态 :Yellow solid.
- 颜色 :White to Light yellow
1-(3-氯苯胺基)-4-苯基酞嗪性质、用途与生产工艺
- 生物活性 MY-5445 是一种特异性的 cGMP 磷酸二酯酶 PDE5 抑制剂，其 Ki 值为 1.3 μM。MY-5445 能抑制人血小板凝集。MY-5445 是一种 ABCG2 转运蛋白调节剂，具有抗增殖活性。
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靶点
PDE5
1.3 μM (Ki)
PDE5
6.7 μM (IC 50 )
PDE4
37 μM (IC 50 )
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体外研究
MY-5445 inhibits human platelet aggregation by increasing cyclic GMP content and that it provides a useful probe for elucidating the role of cyclic GMP in platelet aggregation .
MY-5445 selectively reverses ABCG2-mediated multidrug resistance in ABCG2-overexpressing cells.
MY-5445 reverses ABCG2-mediated multidrug resistance (MDR) by potentiating the cytotoxicity of an ABCG2 substrate drug in ABCG2-overexpressing multidrug-resistant cancer cells, possibly by modulating the function and/or the protein expression of ABCG2.
MY-5445 (3 μM; 48 hours) substantially increases the topotecan-induced apoptosis in S1-M1-80 cell.
Apoptosis Analysis
Cell Line: Human S1 colon cancer cells, S1-M1-80 cancer cells Concentration: 3 μM Incubation Time: 48 hours Result: Enhanced drug-induced apoptosis in ABCG2-overexpressing cancer cells. -
体内研究
MY-5445 (0.5-3 mg/kg; i.p.; twice a day; for 15 days) produces a significant relief of mechanical hypersensitivity.
Animal Model: C57BL/6J male mice Dosage: 0.5 mg/kg, 3 mg/kg Administration: Intraperitoneal injection, twice a day, for 15 days Result: Alleviated the cuff-induced allodynia.
- 更新日期：2024/11/08
- 产品编号：HY-100933
- 产品名称：MY-5445
- CAS编号：
- 包装：1 mg
- 价格：304元
- 更新日期：2024/11/08
- 产品编号：HY-100933
- 产品名称：1-(3-氯苯胺基)-4-苯基酞嗪 MY-5445
- CAS编号：78351-75-4
- 包装：5mg
- 价格：900元
- 公司名称：Service Chemical Inc.
- 联系电话：--
- 电子邮件：sales@chemos-group.com
- 国家：德国
- 产品数：6350
- 优势度：71
- 公司名称：BIOTREND Chemicals AG
- 联系电话：--
- 电子邮件：info@biotrend.ch
- 国家：德国
- 产品数：1250
- 优势度：62
