ChemicalBook CAS数据库列表 N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine

N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine

N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine化学性质

N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine性质、用途与生产工艺

生物活性 ABMA 是一种细胞内毒素和病原体的广谱抑制剂。ABMA 有效地保护细胞免受各种毒素和病原体的侵害，包括病毒，细胞内细菌和寄生虫。ABMA 选择性作用于宿主细胞晚期内体，而不是针对毒素或病原体本身，具有广谱抗感染活性。
靶点

Intracellular bacteria
Viruses
Parasite
体外研究

ABMA protects cells against four bacterial toxins ( Corynebacterium diphtheriae (DT; EC ₅₀ of 62.9 μM), Bacillus anthracis (LT), Clostridium difficile toxin B (TcdB; EC ₅₀ of 73.3 µM), Clostridium sordellii lethal toxin (TcsL; EC ₅₀ of 86.7 μM)), three viruses (Ebola (EC ₅₀ of 3.3 µM), rabies (EC ₅₀ of 19.4 µM), dengue-4 virus ( EC ₅₀ of 8.2 µM)), two species of Chlamydiales intracellular bacteria ( Simkania negevensis and Chlamydia trachomatis ), and the parasite Leishmania infantum (EC ₅₀ of 7.1 µM) at micromolar level.
In A549 cells, ABMA treatment induces a decrease in ricin cytotoxicity with an EC ₅₀ of 3.8 µM, and a protection factor (R) at 30 µM ranging from 5 to 10. ABMA retained almost 100% of its biological activity against ricin-induced cytotoxicity up to six days.

体内研究

ABMA (2-200 mg/kg; intraperitoneal injection; female BALB/c mice) treatment protects mice from nasal instillation of an LD ₉₀ of ricin.

Animal Model:	Pathogen-free female BALB/c mice (6 week-old) with ricin
Dosage:	2 mg/kg, 20 mg/kg, 200 mg/kg
Administration:	Intraperitoneal injection
Result:	A statistically significant protection according to survival curves was observed with a single ip dose of 2 mg/kg. The 20 mg/kg dose fully protected animals through to day 21. The 200 mg/kg dose resulted in 80% of protection of mice against ricin challenge with a single animal succumbing on day 15.

N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine上下游产品信息

上游原料

下游产品

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