N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine
N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine
![N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine 结构式](https://img.chemicalbook.com/CAS/20180601/GIF/332108-65-3.gif)
N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine 性质
| 沸点 | 428.2±30.0 °C(Predicted) |
|---|---|
| 密度 | 1.35±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：125 mg/mL（356.85 mM） |
| 酸度系数(pKa) | 9.86±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine 用途与合成方法
Intracellular bacteria
Viruses
Parasite
ABMA protects cells against four bacterial toxins (
Corynebacterium diphtheriae
(DT; EC
50
of 62.9 μM),
Bacillus anthracis
(LT),
Clostridium difficile
toxin B (TcdB; EC
50
of 73.3 µM),
Clostridium sordellii
lethal toxin (TcsL; EC
50
of 86.7 μM)), three viruses (Ebola (EC
50
of 3.3 µM), rabies (EC
50
of 19.4 µM), dengue-4 virus ( EC
50
of 8.2 µM)), two species of Chlamydiales intracellular bacteria (
Simkania negevensis
and
Chlamydia trachomatis
), and the parasite
Leishmania infantum
(EC
50
of 7.1 µM) at micromolar level.
In A549 cells, ABMA treatment induces a decrease in ricin cytotoxicity with an EC
50
of 3.8 µM, and a protection factor (R) at 30 µM ranging from 5 to 10. ABMA retained almost 100% of its biological activity against ricin-induced cytotoxicity up to six days.
ABMA (2-200 mg/kg; intraperitoneal injection; female BALB/c mice) treatment protects mice from nasal instillation of an LD 90 of ricin.
| Animal Model: | Pathogen-free female BALB/c mice (6 week-old) with ricin |
| Dosage: | 2 mg/kg, 20 mg/kg, 200 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | A statistically significant protection according to survival curves was observed with a single ip dose of 2 mg/kg. The 20 mg/kg dose fully protected animals through to day 21. The 200 mg/kg dose resulted in 80% of protection of mice against ricin challenge with a single animal succumbing on day 15. |
N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-124801 | 5 mg | 937 | ||
| 2024-11-08 | HY-124801 | N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine | 332108-65-3 | 10mg | 1500 |
