ChemicalBook CAS数据库列表 CARBOXYAMIDOTRIAZOLE OROTATE
CARBOXYAMIDOTRIAZOLE OROTATE
- CAS号:187739-60-2
- 英文名:CARBOXYAMIDOTRIAZOLE OROTATE
- 中文名:CARBOXYAMIDOTRIAZOLE OROTATE
- CBNumber:CB92627668
- 分子式:C22H16Cl3N7O6
- 分子量:580.76
- MOL File:187739-60-2.mol
CARBOXYAMIDOTRIAZOLE OROTATE化学性质
- 储存条件 :Store at -20°C
- 溶解度 :DMSO: 5 mg/mL (8.61 mM)
- 形态 :Solid
- 颜色 :Light yellow to yellow
CARBOXYAMIDOTRIAZOLE OROTATE性质、用途与生产工艺
- 生物活性 Carboxyamidotriazole Orotate (L-651582 Orotate),是一种口服生物有效的信号转导抑制剂Carboxyamidotriazole (CAI) 的 orotate 盐形式。Carboxyamidotriazole Orotate 是一种非电压性钙通道 (nonvoltage-operated calcium channels) 和钙通道介导的信号通路 (calcium channel-mediated signaling pathways) 的细胞抑制剂,具有抗癌,抗炎活性和抗血管生成作用。
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体外研究
Carboxyamidotriazole Orotate (0.1-10 µM; 24-96 hours) inhibits cell proliferation of LAMA84R and K562R cell lines.
Carboxyamidotriazole Orotate inhibits the phosphorylation of a selected target of Bcr-Abl kinase. Tyrosine phosphorylation of CrkL is reduced by 5 µM Carboxyamidotriazole Orotate treatment.Cell Viability Assay
Cell Line: LAMA84R and K562R cell lines Concentration: 0.1, 1, 5, 10 µM Incubation Time: 24, 48, 72, 96 hours Result: Showed a 50% growth reduction of the chronic myelogenous leukaemia (CML) lines with 5 µM CTO at 96 h time point. Western Blot Analysis
Cell Line: LAMA84R and K562R cell lines Concentration: 0.1, 1, 5 µM Incubation Time: 72 and 96 hours Result: A dose-dependent inhibition of both total and phosphorylated Bcr-Abl levels. -
体内研究
Carboxyamidotriazole Orotate (342, 513 mg/kg; i.p.; Q1D×5 for two rounds) displays antitumor activity on CML xenografts.
Animal Model: Male NOD/SCID mice four-to-five week old Dosage: 342, 513 mg/kg Administration: i.p.; Q1D×5 for two rounds Result: Increase survival.
CARBOXYAMIDOTRIAZOLE OROTATE上下游产品信息
上游原料
下游产品
CARBOXYAMIDOTRIAZOLE OROTATE 试剂级价格
- 更新日期:2024/04/30
- 产品编号:HY-16125
- 产品名称:CARBOXYAMIDOTRIAZOLE OROTATE Carboxyamidotriazole Orotate
- CAS编号:187739-60-2
- 包装:5mg
- 价格:2000元
- 更新日期:2024/04/30
- 产品编号:S2975
- 产品名称:CarboxyaMidotriazole orotate
- CAS编号:187739-60-2
- 包装:5mg
- 价格:2211.3元
CARBOXYAMIDOTRIAZOLE OROTATE生产厂家
- 公司名称:TargetMol Chemicals Inc.
- 联系电话:+1-781-999-5354 +1-00000000000
- 电子邮件:marketing@targetmol.com
- 国家:美国
- 产品数:19892
- 优势度:58
- 公司名称:Aladdin Scientific
- 联系电话:+1-+1(833)-552-7181
- 电子邮件:sales@aladdinsci.com
- 国家:美国
- 产品数:52927
- 优势度:58
- 公司名称:MedChemExpress
- 联系电话:--
- 电子邮件:sales@medchemexpress.com
- 国家:美国
- 产品数:6398
- 优势度:58