CARBOXYAMIDOTRIAZOLE OROTATE
CARBOXYAMIDOTRIAZOLE OROTATE
英文名称:CARBOXYAMIDOTRIAZOLE OROTATE
CAS号:187739-60-2
分子式:C22H16Cl3N7O6
分子量:580.76
EINECS号:
Mol文件:187739-60-2.mol
CARBOXYAMIDOTRIAZOLE OROTATE 用途与合成方法
Carboxyamidotriazole Orotate (L-651582 Orotate),是一种口服生物有效的信号转导抑制剂Carboxyamidotriazole (CAI) 的 orotate 盐形式。Carboxyamidotriazole Orotate 是一种非电压性钙通道 (nonvoltage-operated calcium channels) 和钙通道介导的信号通路 (calcium channel-mediated signaling pathways) 的细胞抑制剂,具有抗癌,抗炎活性和抗血管生成作用。
Carboxyamidotriazole Orotate (0.1-10 µM; 24-96 hours) inhibits cell proliferation of LAMA84R and K562R cell lines.
Carboxyamidotriazole Orotate inhibits the phosphorylation of a selected target of Bcr-Abl kinase. Tyrosine phosphorylation of CrkL is reduced by 5 µM Carboxyamidotriazole Orotate treatment.
Cell Viability Assay
Cell Line: | LAMA84R and K562R cell lines |
Concentration: | 0.1, 1, 5, 10 µM |
Incubation Time: | 24, 48, 72, 96 hours |
Result: | Showed a 50% growth reduction of the chronic myelogenous leukaemia (CML) lines with 5 µM CTO at 96 h time point. |
Western Blot Analysis
Cell Line: | LAMA84R and K562R cell lines |
Concentration: | 0.1, 1, 5 µM |
Incubation Time: | 72 and 96 hours |
Result: | A dose-dependent inhibition of both total and phosphorylated Bcr-Abl levels. |
Carboxyamidotriazole Orotate (342, 513 mg/kg; i.p.; Q1D×5 for two rounds) displays antitumor activity on CML xenografts.
Animal Model: | Male NOD/SCID mice four-to-five week old |
Dosage: | 342, 513 mg/kg |
Administration: | i.p.; Q1D×5 for two rounds |
Result: | Increase survival. |
CARBOXYAMIDOTRIAZOLE OROTATE 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-08-19 | HY-16125 | 1 mg | 650 | ||
2024-08-19 | HY-16125 | CARBOXYAMIDOTRIAZOLE OROTATE | 187739-60-2 | 5mg | 1600 |
CARBOXYAMIDOTRIAZOLE OROTATE供应商 更多
上海碧咸医药科技有限公司
联系电话:021-13816613772 13816613772
产品介绍:
英文名称:CarboxyaMidotriazole orotate
CAS:187739-60-2
纯度:98%
包装信息:1abcd/
备注:现货
上海一飞生物科技有限公司
联系电话:021-65675885 18964387627
产品介绍:
英文名称:Carboxyamidotriazole orotate
CAS:187739-60-2
纯度:99.00%
包装信息:1mg;5mg;10mg
备注:试剂级
上海瀚香生物科技有限公司
联系电话:17754423994 17754423994
产品介绍:
英文名称:Carboxyamidotriazole Orotate
CAS:187739-60-2
纯度:98% HPLC LCMS
包装信息:100g/;500g/
备注:量大优惠,现货促销
ChemeGen 中国
联系电话: 18818260767
产品介绍:
英文名称:Carboxyamidotriazole Orotate
CAS:187739-60-2
纯度:98%
包装信息:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注:品牌:ChemeGen
广州优南科技有限公司
联系电话:020-020-82000279 18988968278
产品介绍:
英文名称:Carboxyamidotriazole Orotate
CAS:187739-60-2
纯度:98%
包装信息:5mg;10mg;50mg;100mg
备注:医药级