ChemicalBook CAS数据库列表 F-AMidine
F-AMidine
- CAS号:877617-45-3
- 英文名:F-AMidine
- 中文名:F-AMidine
- CBNumber:CB92558584
- 分子式:C14H19FN4O2
- 分子量:294.32
- MOL File:877617-45-3.mol
F-AMidine化学性质
- 密度 :1.27±0.1 g/cm3(Predicted)
- 酸度系数(pKa) :13.26±0.46(Predicted)
F-AMidine性质、用途与生产工艺
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用途
An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently m odifying an active site cysteine that is important for its catalytic activity. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine also inhibits PAD1 and PAD3 with IC50 values of 29.5 and 350 μM, respectively. F-amidine is cytotoxic to HL-60, MCF7 and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).
F-AMidine上下游产品信息
上游原料
下游产品
F-AMidine生产厂家
- 公司名称:TORONTO
- 联系电话:--
- 电子邮件:info@trc-canada.com
- 国家:加拿大
- 产品数:6088
- 优势度:71