F-AMidine
中文名称:F-AMidine
英文名称:F-AMidine
CAS号:877617-45-3
分子式:C14H19FN4O2
分子量:294.32
EINECS号:
Mol文件:877617-45-3.mol
F-AMidine 用途与合成方法
用途
An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently m odifying an active site cysteine that is important for its catalytic activity. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine also inhibits PAD1 and PAD3 with IC50 values of 29.5 and 350 μM, respectively. F-amidine is cytotoxic to HL-60, MCF7 and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).
F-AMidine供应商 更多
北京百灵威科技有限公司
联系电话：010-82848833 400-666-7788
产品介绍：
英文名称：F-AMidine
CAS：877617-45-3
包装信息：2.5Mg,25Mg
备注：化学试剂、精细化学品、医药中间体、材料中间体
TargetMol中国（陶术生物）
联系电话： 4008200310
产品介绍：
中文名称：化合物 T24054
英文名称：F-amidine;F amidine,Famidine
CAS：877617-45-3
纯度：98%
包装信息：5 mg
