佐剂肽

概述用途生物活性靶点体外研究体内研究佐剂肽试剂级价格

佐剂肽

CAS号:53678-77-6
英文名:Muramyl Dipeptide
中文名:佐剂肽
CBNumber:CB9237089
分子式:C19H32N4O11
分子量:492.48
MOL File:53678-77-6.mol

佐剂肽化学性质

比旋光度 :D25 +44° (acetic acid)
沸点 :1071.8±65.0 °C(Predicted)
密度 :1.390±0.06 g/cm3(Predicted)
储存条件 :-20°C
溶解度 :H₂O: 10 mg/mL, clear, colorless
酸度系数(pKa) :4.44±0.10(Predicted)
形态 :buffered aqueous solution
颜色 :White to off-white
Merck :13,6329
BRN :4220745
CAS 数据库 :53678-77-6(CAS DataBase Reference)

安全信息

安全说明 :22-24/25
WGK Germany :3
RTECS号 :MA2275260
F :10

佐剂肽性质、用途与生产工艺

概述佐剂肽是指一种通过诱发、加强和/或促进针对抗原的免疫反应来促进或调节抗原功能而作为功能性组分(组合物中)的肽。
用途佐剂肽主要用于医药、化工领域。
生物活性 Muramyl dipeptide (MDP) 是肽聚糖的共有结构单元。Muramyl dipeptide 通过诱导 Runx2 来诱导 bone formation。
靶点
Target Value
Runx2
()

体外研究

Muramyl dipeptide (0.1-10 µg/mL; 24 hours) increases protein expression of Runx2 in a dose-dependent manner.
Muramyl dipeptide (0.1-10 µg/mL; 6 hours) increases mRNA levels of Runx2 in a dose-dependent manner.

Western Blot Analysis

Cell Line:	MC3T3-E1 cells
Concentration:	0.1, 1, 10 µg/mL
Incubation Time:	24 hours
Result:	Increased protein expression of Runx2 in a dose-dependent manner.

RT-PCR

Cell Line:	MC3T3-E1 cells
Concentration:	0.1, 1, 10 µg/mL
Incubation Time:	6 hours
Result:	Increases mRNA levels of Runx2 in a dose-dependent manner.

体内研究

Muramyl dipeptide (1.25 mg/kg; i.p.; twice) alleviates bone loss induced by osteoporosis.

Animal Model:	RANKL-induced osteoporosis model (Five-week-old C57BL/6 mice)
Dosage:	1.25 mg/kg
Administration:	i.p.; twice (RANKL-induced osteoporosis for 3 weeks and euthanized at 4 weeks)
Result:	Significantly enhanced the trabecular bone volume (BV/TV) and trabecular number (Tb.N).