Hygrolidin
- CAS号:83329-73-1
- 英文名:Hygrolidin
- 中文名:Hygrolidin
- CBNumber:CB92219966
- 分子式:C38H58O11
- 分子量:690.86
- MOL File:83329-73-1.mol
- 沸点 :821.1±65.0 °C(Predicted)
- 密度 :1.17±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :Soluble in DMSO
- 形态 :A solid
- 酸度系数(pKa) :3.28±0.10(Predicted)
- 海关编码 :29419000
Hygrolidin性质、用途与生产工艺
- 生物活性 Hygrolidin 是一种 16 元大环内酯类抗生素,来自于吸水链霉菌 (Streptomyces hygroscopicus) D-1166。Hygrolidin 对 Valsa ceratosperma 具有抗真菌活性。Hygrolidin 诱导 p21 表达并中止 G1 和 S 期的细胞周期进程。Hygrolidin 具有抗肿瘤活性。
-
体外研究
Hygrolidin (0.1, 1 μg/ml; for 24 h) increases both G1 and S phase populations and decreases M phase population.
Hygrolidin (0.1, 1, 10 μg/ml; for 24 h) decreases the amounts of cdk4, cyclin D, cyclin B and increases the amounts of cyclin E and p21. Hygrolidin-induced p21 preferentially associates with cyclin A-cdk2 complex and inhibits it.
Hygrolidin (0.1, 1 μg/ml; for 24 h) selectively induces p21 in DLD-1 cells at mRNA level, but not in WI-38 fibroblasts.
Hygrolidin, for 3 days, inhibits growth of various cell lines including DLD-1 colon cancer, LNCaP prostate cancer, K562 leukemia cells, LNCaP prostate cancer, EL-4 lymphoma (IC 50 s = 1.0-33 ng/ml, respectively).
Hygrolidin shows growth inhibition on Trypanosoma cruzi (IC 50 =1.1 nM), Trypanosoma brucei brucei (IC 50 =77 nM), and Leishmania donovani (IC 50 =72.5 nM).
Cell Cycle Analysis
Cell Line: DLD-1 cells Concentration: 0.1, 1 μg/ml Incubation Time: For 24 hours Result: Increased both G1 and S phase populations and decreased M phase population. Western Blot Analysis
Cell Line: DLD-1 cells Concentration: 0.1, 1, 10 μg/ml Incubation Time: For 24 hours Result: Decreased the amounts of cdk4, cyclin D, cyclin B and increased the amounts of cyclin E and p21. RT-PCR
Cell Line: DLD-1 or WI-38 cells Concentration: 0.1, 1 μg/ml Incubation Time: For 24 hours Result: Selectively induced p21 in DLD-1 cells at mRNA level, but not in WI-38 fibroblasts.
- 公司名称:Novachemistry
- 联系电话:44-20819178-90 02081917890
- 电子邮件:info@novachemistry.com
- 国家:英国
- 产品数:4381
- 优势度:58
- 公司名称:APOLLO-NMR
- 联系电话:--
- 电子邮件:sales@apolloscientific.co.uk
- 国家:英国
- 产品数:6097
- 优势度:88