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ChemicalBook  CAS数据库列表  Hygrolidin

Hygrolidin

生物活性 体外研究
Hygrolidin,83329-73-1,结构式
Hygrolidin
  • CAS号:83329-73-1
  • 英文名:Hygrolidin
  • 中文名:Hygrolidin
  • CBNumber:CB92219966
  • 分子式:C38H58O11
  • 分子量:690.86
  • MOL File:83329-73-1.mol
Hygrolidin化学性质
  • 沸点 :821.1±65.0 °C(Predicted)
  • 密度 :1.17±0.1 g/cm3(Predicted)
  • 储存条件 :Store at -20°C
  • 溶解度 :Soluble in DMSO
  • 形态 :A solid
  • 酸度系数(pKa) :3.28±0.10(Predicted)
安全信息
  • 海关编码 :29419000

Hygrolidin性质、用途与生产工艺

  • 生物活性 Hygrolidin 是一种 16 元大环内酯类抗生素，来自于吸水链霉菌 (Streptomyces hygroscopicus) D-1166。Hygrolidin 对 Valsa ceratosperma 具有抗真菌活性。Hygrolidin 诱导 p21 表达并中止 G1 和 S 期的细胞周期进程。Hygrolidin 具有抗肿瘤活性。
  • 体外研究

    Hygrolidin (0.1, 1 μg/ml; for 24 h) increases both G1 and S phase populations and decreases M phase population.
    Hygrolidin (0.1, 1, 10 μg/ml; for 24 h) decreases the amounts of cdk4, cyclin D, cyclin B and increases the amounts of cyclin E and p21. Hygrolidin-induced p21 preferentially associates with cyclin A-cdk2 complex and inhibits it.
    Hygrolidin (0.1, 1 μg/ml; for 24 h) selectively induces p21 in DLD-1 cells at mRNA level, but not in WI-38 fibroblasts.
    Hygrolidin, for 3 days, inhibits growth of various cell lines including DLD-1 colon cancer, LNCaP prostate cancer, K562 leukemia cells, LNCaP prostate cancer, EL-4 lymphoma (IC 50 s = 1.0-33 ng/ml, respectively).
    Hygrolidin shows growth inhibition on Trypanosoma cruzi (IC 50 =1.1 nM), Trypanosoma brucei brucei (IC 50 =77 nM), and Leishmania donovani (IC 50 =72.5 nM).

    Cell Cycle Analysis

    Cell Line: DLD-1 cells
    Concentration: 0.1, 1 μg/ml
    Incubation Time: For 24 hours
    Result: Increased both G1 and S phase populations and decreased M phase population.

    Western Blot Analysis

    Cell Line: DLD-1 cells
    Concentration: 0.1, 1, 10 μg/ml
    Incubation Time: For 24 hours
    Result: Decreased the amounts of cdk4, cyclin D, cyclin B and increased the amounts of cyclin E and p21.

    RT-PCR

    Cell Line: DLD-1 or WI-38 cells
    Concentration: 0.1, 1 μg/ml
    Incubation Time: For 24 hours
    Result: Selectively induced p21 in DLD-1 cells at mRNA level, but not in WI-38 fibroblasts.
Hygrolidin上下游产品信息
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Hygrolidin生产厂家
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