杯苋甾酮
- CAS号:17086-76-9
- 英文名:Cyasterone
- 中文名:杯苋甾酮
- CBNumber:CB9167302
- 分子式:C29H44O8
- 分子量:520.65
- MOL File:17086-76-9.mol
- 熔点 :164～166℃
- 沸点 :735.2±60.0 °C(Predicted)
- 密度 :1.31±0.1 g/cm3(Predicted)
- 储存条件 :under inert gas (nitrogen or Argon) at 2–8 °C
- 溶解度 :Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- 形态 :Powder
- 酸度系数(pKa) :14.12±0.70(Predicted)
- 颜色 :White to off-white
- 安全说明 :24/25
- 海关编码 :29322090
杯苋甾酮性质、用途与生产工艺
- 生物活性 Cyasterone，一种天然的 EGFR 抑制剂，主要分离自 Ajuga decumbens Thunb (Labiatae)。Cyasterone 通过诱导细胞凋亡 (apoptosis) 和细胞周期阻滞表现出抗增殖作用。 Cyasterone 可用于抗人类肿瘤的相关研究。
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靶点
IC50: EGFR
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体外研究
Cyasterone exerts cytotoxicity on multiple cell lines: HeLa (IC 50 =77.24 μg/ml); HepG-2 (IC 50 =52.03 μg/ml); MCF-7 (IC 50 =82.07 μg/ml) and MCF-7 (IC 50 =82.07 μg/ml). And It has none cytotoxicity (IC 50 >400 μg/ml) on 3 types of carcinoma (HT-29, Caco-2, T47D) and 1 type of normal (NIH 3T3) cell lines. Cyasterone (0-60 μg/ml; 48 hours) causes a significantly decreasing of the cell proliferation. It inhibits cell growth as a dose-dependent manner, exhibits IC 50 values of 38.50 μg/ml and 32.96 μg/ml, respectively. Cyasterone (0-60 μg/ml; 24 hours) decreases p-EGFR, p-MEK, and p-mTOR as a dose-dependent manner in A549 cells, it affects the MAPK signaling pathway activities.
Cell Viability Assay
Cell Line: A549 cells and MGC823 cells Concentration: 0 μg/ml, 20 μg/ml, 40 μg/ml, 60 μg/ml Incubation Time: 24 hours Result: Inhibited cell proliferation as a dose-dependent manner. Western Blot Analysis
Cell Line: A549 cells Concentration: 0 μg/ml, 20 μg/ml, 40 μg/ml, 60 μg/ml Incubation Time: 24 hours Result: Surpressed p-EGFR, p-MEK, and p-mTOR expression. -
体内研究
Cyasterone (intraperitoneal injection; 5 mg/kg, 10 mg/kg and 15 mg/kg; 21 days) has anti-proliferation effect in vivo and inhibits MGC823 cells xenografted tumor growth in vivo with few changes in body weights.
Animal Model: MGC823 xenograft tumor in BALB/C-nu mice Dosage: 5 mg/kg, 10 mg/kg and 15 mg/kg Administration: Intraperitoneal injection Result: Inhibited MGC823 xenograft tumor growth in vivo. - 化学性质 白色结晶，溶于甲醇、乙醇、DMSO，来源于川牛膝CyathulaofficinalisKuan的干燥根。
- 用途 杯苋甾酮有抗生育，活血，利胆，降脂的作用。
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用途
用于含量测定/鉴定/药理实验等。
药理药效:养血舒筋, 祛风除湿。
- 更新日期：2024/08/19
- 产品编号：HY-N0211
- 产品名称：Cyasterone
- CAS编号：
- 包装：1 mg
- 价格：304元
- 更新日期：2024/08/19
- 产品编号：HY-N0211
- 产品名称：杯苋甾酮 Cyasterone
- CAS编号：17086-76-9
- 包装：5mg
- 价格：800元
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6124
- 优势度：58
