补骨脂乙素
- CAS号:20784-50-3
- 英文名:ISOBAVACHALCONE
- 中文名:补骨脂乙素
- CBNumber:CB91412753
- 分子式:C20H20O4
- 分子量:324.37
- MOL File:20784-50-3.mol
- 熔点 :156.8-157.8 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
- 沸点 :549.0±50.0 °C(Predicted)
- 密度 :1.243±0.06 g/cm3(Predicted)
- 储存条件 :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- 溶解度 :Soluble in DMSO
- 形态 :Yellow oil.
- 酸度系数(pKa) :7.99±0.40(Predicted)
- 颜色 :Yellow-orange
补骨脂乙素性质、用途与生产工艺
- 生物活性 Isobavachalcone (Corylifolinin) 来源于补骨脂，是一种 Akt 信号通路的有效抑制剂，可诱导人类癌细胞凋亡 (以 IC50 值为 7.92 μM 抑制 OVCAR-8 癌细胞生长)，具有抗癌和抗增殖活性。Isobavachalcone 还能诱导 OVCAR-8 细胞中活性氧的产生。
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靶点
IC50: 7.92 μM (OVCAR-8 cell)
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体外研究
Isobavachalcone (6.0-48.0 μM; 72 hours; OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells) treatment inhibits the proliferation of human cancer cells. Isobavachalcone inhibits PC3, A549, MCF-7, L-02 and HUVEC cells growth with IC50 values of 15.06 μM, 32.2 μM, 28.29 μM, 31.61 μM and 31.3 μM, respectively.
Isobavachalcone (0-18 μM; 6 hours; OVCAR-8 and PC3 cells) treatment results in a concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt and GSK3b phosphorylation.
Isobavachalcone (0-18 μM; 72 hours; OVCAR-8 and PC3 cells) treatment causes apoptosis via caspase- and ROS-involved mitochondrial pathway.
Cell Proliferation Assay
Cell Line: OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells Concentration: 6.0-48.0 μM Incubation Time: 72 hours Result: Inhibited the proliferation of human cancer cells. Western Blot Analysis
Cell Line: OVCAR-8 or PC3 cells Concentration: 0 μM, 6 μM, 12 μM, and 18 μM Incubation Time: 6 hours Result: A concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt. GSK3b phosphorylation was also inhibited in a concentration- and time-dependent manner. Apoptosis Analysis
Cell Line: OVCAR-8 cells and PC3 cells Concentration: 0 μM, 6 μM, 12 μM, and 18 μM Incubation Time: 72 hours Result: Led to dose dependent increase of apoptosis. -
体内研究
Isobavachalcone (20 mg/kg; intraperitoneal injection; for 0.5-24 hours; female Kunming mice) treatment results in an increase in blood glucose levels, reaching a maximum within 1 hour and maintaining until 4 hours post-dosing.
Animal Model: Seven-week-old specific pathogen-free female Kunming mice (18-22 g) Dosage: 20 mg/kg Administration: Intraperitoneal injection; for 0.5, 1, 2, 4, 6, 8, 12, 24 hours Result: Increased in blood glucose levels. - 化学性质 黄色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于补骨脂PsoraleacorylifoliaLinn.。
- 用途 补骨脂乙素具有抗菌，抗癌的药理活性作用。
- 用途 具有抑制脂多糖诱导的icam-1表达和白细胞与脑内皮细胞粘附的作用
- 更新日期：2024/11/08
- 产品编号：HY-13065
- 产品名称：Isobavachalcone
- CAS编号：
- 包装：1 mg
- 价格：320元
- 更新日期：2024/11/08
- 产品编号：HY-13065
- 产品名称：补骨脂乙素 Isobavachalcone
- CAS编号：20784-50-3
- 包装：5 mg
- 价格：804元
- 公司名称：Ambinter
- 联系电话：--
- 电子邮件：contact@ambinter.com
- 国家：法国
- 产品数：1648
- 优势度：60
