牛磺鹅去氧胆酸

生物活性靶点体外研究体内研究牛磺鹅去氧胆酸试剂级价格

牛磺鹅去氧胆酸

CAS号:516-35-8
英文名:Taurochenodeoxycholic acid
中文名:牛磺鹅去氧胆酸
CBNumber:CB91236274
分子式:C26H45NO6S
分子量:499.7
MOL File:516-35-8.mol

牛磺鹅去氧胆酸化学性质

熔点 :186-200°C
密度 :1.216±0.06 g/cm3(Predicted)
储存条件 :Sealed in dry,Room Temperature
溶解度 :Chloroform, Methanol
形态 :Solid
酸度系数(pKa) :1.42±0.50(Predicted)
颜色 :White to Pale Beige

牛磺鹅去氧胆酸性质、用途与生产工艺

生物活性 Taurochenodeoxycholic acid (12-Deoxycholyltaurine) 是动物胆汁酸的主要生物活性物质之一。Taurochenodeoxycholic acid 可诱导细胞凋亡 (apoptosis)，并具有明显的抗炎和免疫调节作用。
靶点

Human Endogenous Metabolite
体外研究

Taurochenodeoxycholic acid (12-Deoxycholyltaurine) dramatically improves the apoptosis rate of NR8383 cells in a concentration-dependent manner. In the meantime, Taurochenodeoxycholic acid significantly augments PKC mRNA levels, activities and increases JNK, caspase-3 and caspase-8 mRNA expression levels, activities.
体内研究

Taurochenodeoxycholic acid (12-Deoxycholyltaurine; 0.05, 0.1g/kg) decreases the pulmonary coefficient in the model mice and reduces the pathological damages on their lungs; it can decrease the expression levels of TNF-α and TIMP-2 in pulmonary tissues in the pulmonary fibrosis mice and has no significant effects on MMP2.
Taurochenodeoxycholic acid significantly normalizes the clinical inflammatory parameters, prevented indomethacin-induced increases in the biliary contents of secondary bile acids and hydrophobicity index, and tended to attenuate the intestinal inflammation.
Taurochenodeoxycholic acid significantly suppresses paw swelling and polyarthritis index, increases the loss body weight and index of thymus and spleen, and amends radiologic changes in AA rats. The overproduction and mRNA expression of TNF-α, IL-1β and IL-6 are remarkably suppressed in serum and synovium tissue of all TCDCA-treated rats.
化学性质白色结晶体，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于动物胆汁。
用途用于含量测定/鉴定/药理实验等。