生物活性 靶点 体外研究 体内研究 牛磺鹅去氧胆酸钠 试剂级价格
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牛磺鹅去氧胆酸钠

牛磺鹅去氧胆酸钠,6009-98-9,结构式
牛磺鹅去氧胆酸钠
  • CAS号:6009-98-9
  • 英文名:TAUROCHENODEOXYCHOLIC ACID SODIUM SALT
  • 中文名:牛磺鹅去氧胆酸钠
  • CBNumber:CB1277818
  • 分子式:C26H44NNaO6S
  • 分子量:521.69
  • MOL File:6009-98-9.mol
牛磺鹅去氧胆酸钠化学性质
  • 熔点 :165-175 °C
  • 储存条件 :room temp
  • 溶解度 :Methanol (Slightly), Water (Slightly)
  • 形态 :Solid
  • 颜色 :White to Off-White
  • BRN :3901205
  • 稳定性 :Hygroscopic
  • CAS 数据库 :6009-98-9(CAS DataBase Reference)
安全信息
  • 安全说明 :24/25
  • WGK Germany :3
  • F :3-10
  • 海关编码 :29309090

牛磺鹅去氧胆酸钠性质、用途与生产工艺

  • 生物活性 Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) 是动物胆汁酸的主要生物活性物质之一。Taurochenodeoxycholic acid 可诱导细胞凋亡 (apoptosis),并具有明显的抗炎和免疫调节作用。
  • 靶点

    Human Endogenous Metabolite

  • 体外研究

    Taurochenodeoxycholic acid dramatically improves the apoptosis rate of NR8383 cells in a concentration-dependent manner. In the meantime, Taurochenodeoxycholic acid significantly augments PKC mRNA levels, activities and increases JNK, caspase-3 and caspase-8 mRNA expression levels, activities.

  • 体内研究

    Taurochenodeoxycholic acid (0.05, 0.1g/kg) decreases the pulmonary coefficient in the model mice and reduces the pathological damages on their lungs; it can decrease the expression levels of TNF-α and TIMP-2 in pulmonary tissues in the pulmonary fibrosis mice and has no significant effects on MMP2.
    Taurochenodeoxycholic acid significantly normalizes the clinical inflammatory parameters, prevented indomethacin-induced increases in the biliary contents of secondary bile acids and hydrophobicity index, and tended to attenuate the intestinal inflammation.
    Taurochenodeoxycholic acid significantly suppresses paw swelling and polyarthritis index, increases the loss body weight and index of thymus and spleen, and amends radiologic changes in AA rats. The overproduction and mRNA expression of TNF-α, IL-1β and IL-6 are remarkably suppressed in serum and synovium tissue of all TCDCA-treated rats.

  • 用途  生化研究;脂酶加速剂;阴离子去除剂,用于蛋白质的溶解;制备细菌培养基(肠道细菌培养与分离)
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牛磺鹅去氧胆酸钠 试剂级价格
  • 更新日期:2024/11/08
  • 产品编号:HY-N1429
  • 产品名称:牛磺鹅去氧胆酸钠 Taurochenodeoxycholic acid sodium salt
  • CAS编号:6009-98-9
  • 包装:100mg
  • 价格:500元
牛磺鹅去氧胆酸钠生产厂家
  • 公司名称:北京百灵威科技有限公司
  • 联系电话:010-82848833 400-666-7788
  • 电子邮件:jkinfo@jkchemical.com
  • 国家:中国
  • 产品数:94657
  • 优势度:76
  • 公司名称:斯百全化学(上海)有限公司
  • 联系电话:021-021-021-67601398-809-809-809 15221380277
  • 电子邮件:marketing_china@spectrumchemical.com
  • 国家:中国
  • 产品数:9658
  • 优势度:60
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