ChemicalBook CAS数据库列表 硫坎酮
硫坎酮
- CAS号:479-50-5
- 英文名:lucanthone
- 中文名:硫坎酮
- CBNumber:CB8875332
- 分子式:C20H24N2OS
- 分子量:340.48
- MOL File:479-50-5.mol
硫坎酮化学性质
- 熔点 :64.5°C
- 沸点 :512.4±50.0 °C(Predicted)
- 密度 :1.0915 (rough estimate)
- 折射率 :1.5950 (estimate)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO : 25 mg/mL (73.43 mM)
- 酸度系数(pKa) :10.00±0.25(Predicted)
硫坎酮性质、用途与生产工艺
- 生物活性 Lucanthone是新型的自噬抑制剂,也是可用于口服的DNA嵌入剂、DNA修复酶APE1的抑制剂。
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靶点
APE-1
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体外研究
Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. To investigate the anticancer activity of Lucanthone, cell viability is measured by MTT assay. Lucanthone reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC 50 of 7.2 μM versus 66 μM for CQ. Measurement of cell viability in two representative cell lines (MDA-MB-231 and BT-20) by ATPlite assay and trypan blue exclusion reveals comparable results.
硫坎酮上下游产品信息
上游原料
下游产品
硫坎酮 试剂级价格
- 更新日期:2024/04/30
- 产品编号:S6471
- 产品名称:硫坎酮 Lucanthone
- CAS编号:479-50-5
- 包装:2mg
- 价格:876.63元
- 更新日期:2024/04/30
- 产品编号:HY-B2098
- 产品名称:Lucanthone
- CAS编号:
- 包装:10 mM * 1 mLin DMSO
- 价格:1408元
硫坎酮生产厂家
- 公司名称:Pharmaffiliates Analytics and Synthetics P. Ltd
- 联系电话:--
- 电子邮件:mktg@pharmaffiliates.com
- 国家:印度
- 产品数:6773
- 优势度:58
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