硫坎酮
中文名称:硫坎酮
英文名称:lucanthone
CAS号:479-50-5
分子式:C20H24N2OS
分子量:340.48
EINECS号:207-532-4
Mol文件:479-50-5.mol
硫坎酮 性质
熔点 | 64.5°C |
---|---|
沸点 | 512.4±50.0 °C(Predicted) |
密度 | 1.0915 (rough estimate) |
折射率 | 1.5950 (estimate) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:25 mg/mL(73.43 mM) |
形态 | 固体 |
酸度系数(pKa) | 10.00±0.25(Predicted) |
颜色 | 米白色至橙色 |
硫坎酮 用途与合成方法
Lucanthone是新型的自噬抑制剂,也是可用于口服的DNA嵌入剂、DNA修复酶APE1的抑制剂。
APE-1
Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. To investigate the anticancer activity of Lucanthone, cell viability is measured by MTT assay. Lucanthone reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC 50 of 7.2 μM versus 66 μM for CQ. Measurement of cell viability in two representative cell lines (MDA-MB-231 and BT-20) by ATPlite assay and trypan blue exclusion reveals comparable results.
硫坎酮 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-11-08 | HY-B2098 | 硫坎酮 | 479-50-5 | 1mg | 520 |
2024-11-08 | HY-B2098 | 硫坎酮 | 479-50-5 | 5mg | 1280 |
硫坎酮供应商 更多
上海毕得医药科技股份有限公司
联系电话:400-164-7117 13681763483
产品介绍:
中文名称:1-((2-(二乙氨基)乙基)氨基)-4-甲基-9H-硫杂蒽-9-酮
英文名称:1-((2-(Diethylamino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one
CAS:479-50-5
纯度:99+%
包装信息:25mg;50mg;100mg;250mg;
备注:BD136833
上海昶衍化工科技有限公司
联系电话:021-20242659 18930833303
产品介绍:
英文名称:Lucanthone
CAS:479-50-5
纯度:95% HPLC
包装信息:5KG;1KG;500G;100G;50G