异欧前胡素

药理作用羌活中异欧前胡素的含量测定生物活性靶点体外研究异欧前胡素试剂级价格

异欧前胡素

CAS号:482-45-1
英文名:Isoimperatorin
中文名:异欧前胡素
CBNumber:CB8728551
分子式:C16H14O4
分子量:270.28
MOL File:482-45-1.mol

异欧前胡素化学性质

熔点 :107-111°C
沸点 :448.3±45.0 °C(Predicted)
密度 :1.242±0.06 g/cm3(Predicted)
储存条件 :Sealed in dry,2-8°C
溶解度 :Chloroform (Sparingly), Ethyl Acetate (Slightly
颜色 :White to Pale Yellow
BRN :1291723
LogP :3.495 (est)
CAS 数据库 :482-45-1(CAS DataBase Reference)
NIST化学物质信息 :7H-furo[3,2-g][1]benzopyran-7-one, 4-[(3-methyl-2-butenyl)oxy]-(482-45-1)

安全信息

安全说明 :24/25
WGK Germany :3
RTECS号 :LV1513000
海关编码 :29329990
毒害物质数据 :482-45-1(Hazardous Substances Data)

异欧前胡素性质、用途与生产工艺

药理作用分子式C16H14O4，分子量270.27，无色针状结晶(乙醇)，熔点110～111℃。
异欧前胡素具有降压、解痉、抗癌的作用，还可以治疗银屑病。
羌活中异欧前胡素的含量测定 [色谱条件]
色谱柱：μbondapak C18柱(150mm×6mm， 5μm);流动相：甲醇-乙腈-0.25mol/L磷酸溶液(9：5：10);流速：1.0ml/min;检测波长：322nm;柱温：室温。
[供试品的制备]
取本品粗粉约50g，用8倍量90%乙醇回流提取3次，每次1.5h，合并提取液，回收乙醇，得浸膏13.70g，并将其与适量经处理过的大孔吸附树脂拌匀，置于经处理过的大孔吸附树脂柱上，依次用水，20%、30%、40%、50%、60%、70%、80%、90%的乙醇冲洗，每次冲至洗脱液无色，水浴蒸干，得膏状物，分别用50%乙醇溶解，定容至50ml。按本法色谱条件进行测定。
生物活性 Isoimperatorin 是Angelica dahurica 根的甲醇提取物，有效抑制乙酰胆碱酯酶 (AChE)，IC50 为 74.6 μM。
靶点
Target Value
AChE
(Cell-free assay) 74.6 μM
体外研究

During a screening program for new agrochemicals from Chinese medicinal herbs, the ethanol extract of Notopterygium incisum rhizomes is found to possess strong nematicidal activity against the two species of nematodes, Bursaphelenchus xylophilus and Meloidogyne incognita . Based on bioactivity-guided fractionation, the four constituents are isolated from the ethanol extract and identified as Columbianetin, Falcarindiol, Falcarinol, and Isoimperatorin. Isoimperatorin also has LC ₅₀ values of 21.83 μg/mL against B. xylophilus . When using 15 min UV light treatment, falcarindiol, falcarinol, and isoimperatorin demonstrated almost five times more toxic to the southern root-knot nematodes than in dark treatment while columbianetin showed only two times more toxic. isoimperatorin has been demonstrated to possess insecticidal activity against several insects, such as the cabbage aphid ( Brevicoryne brassicae ). Isoimperatorin is identified in the active fraction of Angelica dahurica (AD) extract. Isoimperatorin is usually used as the internal standard (IS).
化学性质来源于大风子科罗旦梅 Flacourtiajangomas(Lour.)Raeusch茎,皮
用途用于含量测定/鉴定/药理实验等。