N-叔丁基-#-苯基硝酮
- CAS号:3376-24-7
- 英文名:N-TERT-BUTYL-ALPHA-PHENYLNITRONE
- 中文名:N-叔丁基-#-苯基硝酮
- CBNumber:CB8469861
- 分子式:C11H15NO
- 分子量:177.24
- MOL File:3376-24-7.mol
- 熔点 :73-74 °C(lit.)
- 沸点 :283℃
- 密度 :0.990
- 折射率 :1.5480 (estimate)
- 闪点 :119℃
- 储存条件 :Store at <= 20°C.
- 溶解度 :DMSO: soluble
- 形态 :powder
- 酸度系数(pKa) :1.50±0.53(Predicted)
- 颜色 :white
- 水溶解性 :Soluble in DMSO (10 mg/ml), chloroform (50 mg/ml), and water (20 mg/ml).
- Merck :14,7056
- BRN :2044028
- CAS 数据库 :3376-24-7(CAS DataBase Reference)
- EPA化学物质信息 :2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide (3376-24-7)
N-叔丁基-#-苯基硝酮性质、用途与生产工艺
- 生物活性 N-tert-Butyl-α-phenylnitrone 是一种基于硝酮的自由基清除剂，可形成一氧化氮自旋加合物。N-tert-Butyl-α-phenylnitrone 抑制 COX2 的催化活性。N-tert-Butyl-α-phenylnitrone 具有有效的 ROS 清除，抗炎，神经保护，抗衰老和抗糖尿病的作用，并且可以穿透血脑屏障。
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靶点
COX-2
Reactive oxygen species (ROS)
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体外研究
N-tert-Butyl-α-phenylnitrone (PBN) (25-100 µM) treatment leads to a significant decrease in 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced intracellular ROS accumulation. N-tert-Butyl-α-phenylnitrone also attenuates AAPH-induced cytotoxicity, matrix degradation, and apoptosis. N-tert-Butyl-α-phenylnitrone suppresses AAPH-induced activation of ERK/MAPK pathway. N-tert-Butyl-α-phenylnitrone has the potenial for intervertebral disc degeneration (IDD) research.
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体内研究
N-tert-Butyl-α-phenylnitrone (PBN; 100 mg/kg; intraperitoneal injection; twice a day; C57Bl/6 mice) treatment not only abolishes the LPS-induced lipid peroxidation, nitrotyrosine residue levels, and GSH depletion, but also decreases the incidence of external malformations.
Animal Model: C57Bl/6 mice induced by lipopolysaccharide (LPS) Dosage: 100 mg/kg Administration: Intraperitoneal injection; twice a day (on gestational day 8) Result: Abolished LPS-induced lipid peroxidation, nitrotyrosine residues, and GSH depletion. - 用途 自旋捕集剂。
- 用途 一种Cox-2抑制剂。
- 更新日期：2024/11/08
- 产品编号：A17442
- 产品名称：N-叔丁基-α-苯基硝酮, 98% N-tert-Butyl-alpha-phenylnitrone, 98%
- CAS编号：3376-24-7
- 包装：1g
- 价格：633元
- 更新日期：2024/11/08
- 产品编号：A17442
- 产品名称：N-叔丁基-α-苯基硝酮, 98% N-tert-Butyl-alpha-phenylnitrone, 98%
- CAS编号：3376-24-7
- 包装：5g
- 价格：2541元
- 公司名称：TCI Europe
- 联系电话：320-37350700
- 电子邮件：sales@tcieurope.eu
- 国家：欧洲
- 产品数：23671
- 优势度：75
