氟伏沙明
- CAS号:54739-18-3
- 英文名:Fluvoxamine
- 中文名:氟伏沙明
- CBNumber:CB8468990
- 分子式:C15H21F3N2O2
- 分子量:318.33
- MOL File:54739-18-3.mol
- 熔点 :120-122.5°C
- 沸点 :370.6±52.0 °C(Predicted)
- 密度 :1.16±0.1 g/cm3(Predicted)
- 储存条件 :Sealed in dry,2-8°C
- 溶解度 :Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)
- 形态 :Oil
- 酸度系数(pKa) :pKa 8.7 (Uncertain)
- 颜色 :Colourless
- CAS 数据库 :54739-18-3(CAS DataBase Reference)
- NIST化学物质信息 :Fluvoxamine(54739-18-3)
氟伏沙明 化学药品说明书
氟伏沙明|药物应用信息
氟伏沙明性质、用途与生产工艺
- 生物活性 Fluvoxamine (DU-23000) 是5-羟色胺再吸收抑制剂,有抗抑郁活性。
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靶点
SSRIs.
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体内研究
Fluvoxamine (DU-23000) is effective in inhibiting 5-ht uptake by blood platelets and brain synaptosomes. The antagonism by fluvoxamine of the reserpine-induced lowering of the pentamethylenetetrazole convulsive threshold can be regarded as due to an effect upon 5-HT uptake. In contrast to the effects of desmethylimipramine and imipramine, no stimulatory effects are found in rats when rapidly acting reserpine-like compounds are given following a dose of fluvoxamine. Fluvoxamine (DU-23000) appears to improve combat-related PTSD symptoms but not depressive symptoms. The high attrition rate and lack of a placebo group limits the conclusions of our study. Controlled studies of fluvoxamine in the treatment of PTSD are warranted. Fluvoxamine (DU-23000) was less potent at decreasing ethanol self-administration when food was available concurrently versus when ethanol was available in isolation [ED50: 4.0 (2.7-5.9) and 5.1 (4.3-6.0)]. Effects on food were similar under each condition in which food was available. The results demonstrate that the potency of fluvoxamine in reducing ethanol-maintained behavior depends on whether ethanol is available in isolation or in the context of concurrently scheduled food reinforcement.
- 更新日期:2024/11/08
- 产品编号:HY-B0103
- 产品名称:Fluvoxamine
- CAS编号:
- 包装:5 mg
- 价格:240元
- 更新日期:2024/11/08
- 产品编号:HY-B0103
- 产品名称:Fluvoxamine
- CAS编号:
- 包装:10 mM * 1 mLin DMSO
- 价格:264元
- 公司名称:Portail Substances Chimiques
- 联系电话:--
- 电子邮件:webmestre-substances@ineris.fr
- 国家:法国
- 产品数:6024
- 优势度:58