4',6,7-三羟异黄酮
- CAS号:17817-31-1
- 英文名:6,7,4'-Trihydroxyisoflavone
- 中文名:4',6,7-三羟异黄酮
- CBNumber:CB8397160
- 分子式:C15H10O5
- 分子量:270.24
- MOL File:17817-31-1.mol
- 熔点 :>280℃
- 沸点 :587.1±50.0 °C(Predicted)
- 密度 :1.548±0.06 g/cm3(Predicted)
- 储存条件 :2-8°C
- 溶解度 :soluble in Dimethylformamide
- 形态 :powder to crystal
- 酸度系数(pKa) :6.85±0.20(Predicted)
- 颜色 :Light yellow to Brown to Dark green
- LogP :2.170 (est)
- CAS 数据库 :17817-31-1(CAS DataBase Reference)
4',6,7-三羟异黄酮性质、用途与生产工艺
- 生物活性 Desmethylglycitein (4',6,7-Trihydroxyisoflavone)，大豆苷元的代谢产物，来源于大豆 Glycine max，具有抗氧化性和抗癌活性。Desmethylglycitein 在体内直接结合 CDK1 和 CDK2，抑制 CDK1 和 CDK2 活性。Desmethylglycitein 是蛋白激酶 C (PKC)α 的直接抑制剂，抑制正常人皮肤成纤维细胞中的太阳紫外线 (sUV) 诱导的基质金属蛋白酶1 (MMP1)。Desmethylglycitein 以 ATP 竞争方式与细胞质中的 PI3K 结合，抑制 PI3K 和下游信号级联的活性，从而抑制 3T3-L1 前脂肪细胞中的脂肪形成。
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靶点
CDK1
CDK2
PKC
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体外研究
Desmethylglycitein (4',6,7-Trihydroxyisoflavone)(0-100 μM; 24-72 hours) suppesses anchorage-dependent growth of HCT-116 and DLD1 cells in a dose- and time-dependent manner without cytotoxicity . Desmethylglycitein (4',6,7-Trihydroxyisoflavone)(0-100 μM; 24-72 hours) suppresses CDK1 activity in a dose-dependent manner and inhibits CDK2 activity in HCT-116 cells. Desmethylglycitein (4',6,7-Trihydroxyisoflavone)(0-100 μM; 24-72 hours) induces cell cycle arrest at the S and G2/M phases, the percentage of cells in S phase is higher in the 100 μM 6,7,4′-THIF-treated group, and the same pattern is observed in G2/M phase (29.5% versus 19.1% ) .
Cell Viability Assay
Cell Line: HCT-116 cells Concentration: 0, 12.5, 25, 50 or 100 μM Incubation Time: 24, 48 or 72 hours Result: Inhibited anchorage-dependent and -independent growth of HCT-116 cells. Western Blot Analysis
Cell Line: HCT-116 and DLD1 cells Concentration: 0, 25, 50 or 100 μM Incubation Time: 48 hours Result: Inhibited CDK1,CDK2 expression. Cell Cycle Analysis
Cell Line: HCT-116 cells Concentration: 0, 25, 50 or 100 μM Incubation Time: 24, 48 or 72 hours Result: Induces cell cycle arrest of HCT-116 cells at S and G2/M phases. -
体内研究
Desmethylglycitein (4',6,7-Trihydroxyisoflavone) (intraperitoneally injection; 5 or 25 mg/kg; once daily; 20 days) suppresses tumor development in mice and serves as an effective anticancer treatment with the potential to inhibit or delay the tumorigenicity of HCT-116 cells in an in vivo system.
Animal Model: Female athymic nude mice subcutaneously injected with HCT-116 cells Dosage: 5 or 25 mg/kg Administration: Intraperitoneally injection; 5 or 25 mg/kg; once daily; 20 days Result: Decreased tumor growth, volume and weight of HCT-116 xenografts.
- 更新日期：2024/11/08
- 产品编号：HY-N5072
- 产品名称：4',6,7-三羟异黄酮 Desmethylglycitein
- CAS编号：17817-31-1
- 包装：5mg
- 价格：300元
- 更新日期：2024/11/08
- 产品编号：HY-N5072
- 产品名称：Desmethylglycitein
- CAS编号：
- 包装：10 mM * 1 mLin DMSO
- 价格：330元
- 公司名称：Carbosynth
- 联系电话：--
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- 国家：英国
- 产品数：6005
- 优势度：58
- 公司名称：Apin Chemicals Limited (UK)
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- 电子邮件：info@apinchemicals.com
- 国家：英国
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- 公司名称：Carbone Scientific CO., LTD
- 联系电话：--
- 电子邮件：sales@carbonesci.com
- 国家：英国
- 产品数：6666
- 优势度：30
- 公司名称：APIN-NP
- 联系电话：--
- 电子邮件：info@apinchemicals.com
- 国家：英国
- 产品数：6807
- 优势度：42
