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消旋型二氟甲基腈盐酸盐

消旋型二氟甲基腈盐酸盐,70052-12-9,结构式
消旋型二氟甲基腈盐酸盐
  • CAS号:70052-12-9
  • 英文名:DFMO
  • 中文名:消旋型二氟甲基腈盐酸盐
  • CBNumber:CB8373227
  • 分子式:C6H12F2N2O2
  • 分子量:182.17
  • MOL File:70052-12-9.mol
消旋型二氟甲基腈盐酸盐化学性质
  • 熔点 :138 °C
  • 沸点 :347.0±42.0 °C(Predicted)
  • 密度 :1.1800 (estimate)
  • 储存条件 :Store at 0°C
  • 溶解度 :H2O: >10 mg/mL, soluble
  • 酸度系数(pKa) :1.22±0.44(Predicted)
  • 形态 :solid
  • 颜色 :white
安全信息

消旋型二氟甲基腈盐酸盐性质、用途与生产工艺

  • 生物活性 Eflornithine (DFMO) 是酶鸟氨酸脱羧酶的特异性不可逆抑制剂。Eflornithine 可用于研究非洲锥虫病和女性面部毛发过度生长。
  • 体内研究

    Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension.

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