ChemicalBook CAS数据库列表 CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE
CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE
- CAS号:153088-73-4
- 英文名:Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE
- 中文名:CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE
- CBNumber:CB8336473
- 分子式:C20H17Cl2NO7
- 分子量:454.26
- MOL File:153088-73-4.mol
CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE化学性质
- 沸点 :674.2±55.0 °C(Predicted)
- 密度 :1.440±0.06 g/cm3(Predicted)
- 储存条件 :−20°C
- 溶解度 :Soluble in DMSO (up to 25 mg/ml).
- 形态 :White to off-white powder.
- 酸度系数(pKa) :4.01±0.19(Predicted)
- 颜色 :white
- 稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
安全信息
- WGK Germany :3
CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE性质、用途与生产工艺
- 生物活性 Z-Asp-CH2-DCB 是一种不可逆的广谱 caspase 抑制剂，Z-Asp-CH2-DCB 也能抑制具有 caspase 样活性的蛋白酶。Z-D-CH2-DCB 并以剂量依赖的方式阻断 PBMC 细胞中的金黄色葡萄球菌肠毒素 B (SEB) 刺激的 IL-1β、TNF-α、IL-6 和 IFN-γ 的产生，和降低 SEB-1 刺激的 T 细胞增殖。Z-Asp-CH2-DCB 可预防 SU5416 诱导的间隔细胞凋亡和肺气肿的发生。
-
体外研究
Z-Asp-CH2-DCB (10-100 μM) blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in SEB-stimulated (200 ng; 16 hours) PBMC in a dose-dependent manner. The production of the chemokines MCP-1, MIP-1α, and MIP-1β was also suppresses. The inhibitory effect of Z-Asp-CH2-DCB on TSST-1-activated PBMC is similar, reducing IL-1β, IL-6, TNF-α, IFN-γ, MCP-1, MIP-1α, and MIP-1β to 10, 36, 25, 10, 11, 25, and 30%, respectively, of levels in untreated cells.
Z-Asp-CH2-DCB (10-100 μM; 48 hours) inhibits T-cell proliferation in PBMC stimulated with 200 ng of SEB/ml .Cell Viability Assay
Cell Line: Human peripheral blood mononuclear cells Concentration: 10, 50, 100 μM Incubation Time: 48 hours Result: Inhibited T-cell proliferation in PBMC stimulated with SEB. -
体内研究
Z-Asp-CH2-DCB (1 mg; i.p.; every day for 3 weeks) prevents SU5416-induced septal cell apoptosis.
Animal Model: Male Sprague-Dawley rats (SU5416+ Z-Asp-CH2-DCB group) Dosage: 1 mg Administration: Intraperitoneal injection; every day for 3 weeks Result: The caspase 3-like activity in SU5416-treated rat lungs is significantly higher, whereas lungs from rats treated with SU5416+Z-Asp-CH2-DCB showed no increase in apoptotic activity.
CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE上下游产品信息
上游原料
下游产品
CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-113953
- 产品名称：CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE Z-Asp-CH2-DCB
- CAS编号：153088-73-4
- 包装：1mg
- 价格：500元
- 更新日期：2024/11/08
- 产品编号：HY-113953
- 产品名称：CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE Z-Asp-CH2-DCB
- CAS编号：153088-73-4
- 包装：5mg
- 价格：800元
CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE生产厂家
- 公司名称：PEPTIDE-INST
- 联系电话：--
- 电子邮件：info@peptide.co.jp
- 国家：日本
- 产品数：992
- 优势度：70
153088-73-4, CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE相关搜索:
- Z-ASP-GLN-MET-ASP-AFC Z-ALA-GLY-OH Z-ALA-SER-OH Z-ALA-PRO-PNA Z-ARG-PNA HCL (3S)-3-[[叔丁氧羰基]氨基]-5-氟-4-氧代-戊酸甲酯 乙酰基缬氨酰谷氨酰异亮氨酰天冬氨酸-7-氨基-4-甲基香豆素 Z-TYR-VAL-ALA-ASP-AFC Α-(三氯甲基)-4-吡啶乙醇 乙酰基-缬氨酰-天冬氨酰-缬氨酰-丙氨酰-天冬氨醛 AC-ASP-GLU-VAL-ASP-7-氨基-4-三氟甲基香豆素 PAC1 乙酰基-天冬氨酰-谷氨酰-缬氨酰-天冬氨醛 AC-VAL-ASP-VAL-ALA-ASP-PNA Z-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONE 2,6-二氯苯甲酸乙酯 2,6-二氯苄基甲基醚 2,6-二氯苯甲酸
