环(组氨酰-脯氨酰)
- CAS号:53109-32-3
- 英文名:CYCLO(-HIS-PRO)
- 中文名:环(组氨酰-脯氨酰)
- CBNumber:CB8279260
- 分子式:C11H14N4O2
- 分子量:234.25
- MOL File:53109-32-3.mol
- 熔点 :162-164 °C
- 沸点 :659.3±48.0 °C(Predicted)
- 密度 :1.41±0.1 g/cm3(Predicted)
- 储存条件 :2-8°C
- 溶解度 :DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 1 mg/ml
- 形态 :A neat oil
- 酸度系数(pKa) :12.73±0.40(Predicted)
- 颜色 :Light yellow to yellow
- WGK Germany :3
环(组氨酰-脯氨酰)性质、用途与生产工艺
- 生物活性 Cyclo(his-pro) (Cyclo(histidyl-proline)) 是一种具有口服活性的，结构上与促甲状腺激素释放激素相关的环状二肽。Cyclo(his-pro) 可以抑制 NF-κB 核积累。Cyclo(his-pro) 可以穿越脑血屏障并影响多种炎症和应激反应。
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靶点
NF-κB
Human Endogenous Metabolite
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体外研究
cyclo(his-pro) (Cyclo(histidyl-proline); 50 μM; 1-48 hours) increases the nuclear level of Nrf2 and inhibits NF-κB nuclear translocation. Cyclo(His-Pro) alone has no effect on nuclear translocation of these transcription factors.
cyclo(his-pro) (50 μM; prior to PQ exposure for 48 hours) abolishes protein nitration that followed paraquat (PQ) exposure and lessenes its functional consequences, as shown by decrease in cell apoptosis, detected by caspase 3 activity and by cytochrome c release.
Cyclo(his-pro) inhibits NF-κB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway.
Western Blot Analysis
Cell Line: PC12 cells Concentration: 50 μM Incubation Time: 1, 2, 4, 8, 24, 48 hours Result: Increased the nuclear level of Nrf2 and inhibited NF-κB nuclear translocation. -
体内研究
Cyclo(his-pro) (Cyclo(histidyl-proline); 1.8 mg/ear; topical application on the right ear; 30 min prior to TPA) reduces TPA-induced ear oedema confirming that it can exert anti-inflammatory effect.
Cyclo(his-pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFα expression thereby counteracting LPS-induced gliosis. Moreover, by up-regulating Bip, Cyclo(his-pro) increases the ER stress sensitivity andtriggers the unfolded protein response to alleviate the ER stress.
Animal Model: Sixty two/three month-old male C57BL/6 mice (25-30 g) Dosage: 1.8 mg/ear Administration: Topical application on the right ear; 30 min prior to TPA Result: Reduced TPA-induced ear oedema.
- 更新日期：2024/11/08
- 产品编号：HY-101402
- 产品名称：环(组氨酰-脯氨酰) Cyclo(his-pro)
- CAS编号：53109-32-3
- 包装：1mg
- 价格：500元
- 更新日期：2024/11/08
- 产品编号：HY-101402
- 产品名称：环(组氨酰-脯氨酰) Cyclo(his-pro)
- CAS编号：53109-32-3
- 包装：5mg
- 价格：900元
- 公司名称：Pharmaffiliates Analytics and Synthetics P. Ltd
- 联系电话：--
- 电子邮件：mktg@pharmaffiliates.com
- 国家：印度
- 产品数：6739
- 优势度：58
- 公司名称：CLEARSYNTH LABS LTD.
- 联系电话：--
- 电子邮件：sales@clearsynth.com
- 国家：印度
- 产品数：6257
- 优势度：58
