环(组氨酰-脯氨酰)
环(组氨酰-脯氨酰) 性质
| 熔点 | 162-164 °C |
|---|---|
| 沸点 | 659.3±48.0 °C(Predicted) |
| 密度 | 1.41±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMF：1mg/mL； DMSO：1mg/mL；乙醇：1mg/mL； PBS（pH 7.2）：1 mg/mL |
| 形态 | 油状物 |
| 酸度系数(pKa) | 12.73±0.40(Predicted) |
| 颜色 | 浅黄至黄色 |
环(组氨酰-脯氨酰) 用途与合成方法
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NF-κB
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Human Endogenous Metabolite
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cyclo(his-pro) (Cyclo(histidyl-proline); 50 μM; 1-48 hours) increases the nuclear level of Nrf2 and inhibits NF-κB nuclear translocation. Cyclo(His-Pro) alone has no effect on nuclear translocation of these transcription factors.
cyclo(his-pro) (50 μM; prior to PQ exposure for 48 hours) abolishes protein nitration that followed paraquat (PQ) exposure and lessenes its functional consequences, as shown by decrease in cell apoptosis, detected by caspase 3 activity and by cytochrome c release.
Cyclo(his-pro) inhibits NF-κB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway.
Western Blot Analysis
| Cell Line: | PC12 cells |
| Concentration: | 50 μM |
| Incubation Time: | 1, 2, 4, 8, 24, 48 hours |
| Result: | Increased the nuclear level of Nrf2 and inhibited NF-κB nuclear translocation. |
Cyclo(his-pro) (Cyclo(histidyl-proline); 1.8 mg/ear; topical application on the right ear; 30 min prior to TPA) reduces TPA-induced ear oedema confirming that it can exert anti-inflammatory effect.
Cyclo(his-pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFα expression thereby counteracting LPS-induced gliosis. Moreover, by up-regulating Bip, Cyclo(his-pro) increases the ER stress sensitivity andtriggers the unfolded protein response to alleviate the ER stress.
| Animal Model: | Sixty two/three month-old male C57BL/6 mice (25-30 g) |
| Dosage: | 1.8 mg/ear |
| Administration: | Topical application on the right ear; 30 min prior to TPA |
| Result: | Reduced TPA-induced ear oedema. |
环(组氨酰-脯氨酰) 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-101402 | 环(组氨酰-脯氨酰) | 53109-32-3 | 1mg | 500 |
| 2024-11-08 | HY-101402 | 环(组氨酰-脯氨酰) | 53109-32-3 | 5mg | 900 |
