硫酸碘苄胍 EP标准品
- CAS号:87862-25-7
- 英文名:3-IODOBENZYL-GUANIDINE HEMISULFATE
- 中文名:硫酸碘苄胍 EP标准品
- CBNumber:CB8278137
- 分子式:C16H22I2N6O4S
- 分子量:648.26
- MOL File:87862-25-7.mol
- 储存条件 :2-8°C
- 溶解度 :DMSO: 2 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml
- 形态 :A crystalline solid
- 颜色 :White to off-white
- WGK Germany :3
- 海关编码 :2909309090
硫酸碘苄胍 EP标准品性质、用途与生产工艺
- 生物活性 Iobenguane sulfate (MIBG sulfate) 是一种具有抗肿瘤活性的神经递质去甲肾上腺素的类似物。放射性碘代 Iobenguane sulfate 可用于肾上腺肿瘤诊断和肿瘤靶向药物的研究。Iobenguane sulfate 是一种高亲和力的霍乱毒素底物，干扰细胞单核(ADP-核糖基化)。
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体外研究
Iobenguane sulfate (MIBG sulfate) (2-20 μg/ml; 72 hours) inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines.
Iobenguane sulfate (MIBG sulfate) is a potent affector of endogenous mono(ADP-ribosyl) transferases of turkey and human erythrocyte membranes, exerting its effect in the μM concentration range.Cell Proliferation Assay
Cell Line: 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, CHP212 cells Concentration: 2, 20μg/ml Incubation Time: 72 hours Result: Inhibits 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, and CHP212 cells growth. -
体内研究
Iobenguane sulfate (MIBG hemisulfate) (20 mg/kg; i.p.; daily on days 3-6) shows antitumor activity.
The survival of male strain AF mice inoculates with N1E115 neuroblastoma and treats according to NIH protocols for new drug testing with 9 daily injections of Iobenguane sulfate (40 mg/kg), Marking prolongation of sugvival but no cures were observed.
Iobenguane sulfate testes for its toxicity on male strain AF (N1Ell5) mice with 5 daily injections. At 50 mg/kg body weight, all animals died after 1-4 doses and 4/16 animals died on a schedule of 44 mg/kg.Animal Model: DBA/2 (L1210)) mice Dosage: i.p.; daily on days 3-6 Administration: 20 mg/kg Result: Considerable prolongation of survival and some cures were obtained.
- 公司名称：Otto Chemie Pvt. Ltd.
- 联系电话：--
- 电子邮件：info@ottokemi.com
- 国家：印度
- 产品数：5870
- 优势度：58
