硫酸碘苄胍 EP标准品
硫酸碘苄胍 EP标准品 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | DMSO：2mg/mL； DMSO:PBS (pH 7.2) (1:4)：0.2 mg/mL |
| 形态 | 结晶固体 |
| 颜色 | 白色至米白色 |
| InChI | 1S/2C8H10IN3.H2O4S/c2*9-7-3-1-2-6(4-7)5-12-8(10)11;1-5(2,3)4/h2*1-4H,5H2,(H4,10,11,12);(H2,1,2,3,4) |
| InChIKey | XNACDNPGABUBFR-UHFFFAOYSA-N |
| SMILES | OS(O)(=O)=O.NC(=N)NCc1cccc(I)c1.NC(=N)NCc2cccc(I)c2 |
硫酸碘苄胍 EP标准品 用途与合成方法
Iobenguane sulfate (MIBG sulfate) (2-20 μg/ml; 72 hours) inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines.
Iobenguane sulfate (MIBG sulfate) is a potent affector of endogenous mono(ADP-ribosyl) transferases of turkey and human erythrocyte membranes, exerting its effect in the μM concentration range.
Cell Proliferation Assay
| Cell Line: | 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, CHP212 cells |
| Concentration: | 2, 20μg/ml |
| Incubation Time: | 72 hours |
| Result: | Inhibits 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, and CHP212 cells growth. |
Iobenguane sulfate (MIBG hemisulfate) (20 mg/kg; i.p.; daily on days 3-6) shows antitumor activity.
The survival of male strain AF mice inoculates with N1E115 neuroblastoma and treats according to NIH protocols for new drug testing with 9 daily injections of Iobenguane sulfate (40 mg/kg), Marking prolongation of sugvival but no cures were observed.
Iobenguane sulfate testes for its toxicity on male strain AF (N1Ell5) mice with 5 daily injections. At 50 mg/kg body weight, all animals died after 1-4 doses and 4/16 animals died on a schedule of 44 mg/kg.
| Animal Model: | DBA/2 (L1210)) mice |
| Dosage: | i.p.; daily on days 3-6 |
| Administration: | 20 mg/kg |
| Result: | Considerable prolongation of survival and some cures were obtained. |
