ChemicalBook CAS数据库列表 BETAMETHASONE HYDROCHLORIDE
BETAMETHASONE HYDROCHLORIDE
- CAS号:956901-32-9
- 英文名:BetaMethasone (hydrochloride)
- 中文名:BETAMETHASONE HYDROCHLORIDE
- CBNumber:CB82677080
- 分子式:C28H38ClFO7
- 分子量:541.0485232
- MOL File:956901-32-9.mol
BETAMETHASONE HYDROCHLORIDE化学性质
- 储存条件 :Store at -20°C
- 溶解度 :Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- 形态 :Powder
BETAMETHASONE HYDROCHLORIDE性质、用途与生产工艺
- 生物活性 Betamethasone hydrochloride 是一种合成糖皮质激素，具有抗炎和免疫抑制活性。Betamethasone hydrochloride 可加速胎儿肺成熟并诱导基因表达和细胞凋亡。
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体外研究
Betamethasone (0.1-1 μM; 12 h) induces gene expression in L929 cells.
Betamethasone (0.1-1 μM; 48 h) induces CEM C7 T-cells apoptosis. -
体内研究
Betamethasone (0.48 mg; i.v.gtt for 48 h) decreases the hypercapnia-induced increase in CBF due to decreased cerebral vasodilatation. Betamethasone (0.05 ml (1 mg/L); topical injection) ameliorates spinal nerve transection induced mechanical allodynia and thermal hyperalgesia, and reduces the activation of NF-κB and elevation of TNFα and IL-1β, and induces the expression of IL-10 in the rats brain.
Animal Model: Rambouillet-Colombia ewes bred on a single occasion are received hypercapnic challenges Dosage: 0.48 mg Administration: Injected into the fetal jugular vein at a rate of 1 ml/h (10 μg betamethasone/h) and maintained over the next 48 h. Result: Decreased cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 h of infusion.
The reduction in CBF was diminished to about 25-30 % after 48 h of infusion.
BETAMETHASONE HYDROCHLORIDE上下游产品信息
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BETAMETHASONE HYDROCHLORIDE生产厂家
- 公司名称：MedChemexpress LLC
- 联系电话：021-58955995
- 电子邮件：sales@medchemexpress.cn
- 国家：美国
- 产品数：4861
- 优势度：58
- 公司名称：Musechem
- 联系电话：+1-800-259-7612
- 电子邮件：info@musechem.com
- 国家：美国
- 产品数：4660
- 优势度：60
- 公司名称：BOC Sciences
- 联系电话： 16314854226
- 电子邮件：info@bocsci.com
- 国家：美国
- 产品数：9923
- 优势度：65
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
