SJG 136
- CAS号:232931-57-6
- 英文名:BN-2629
- 中文名:SJG 136
- CBNumber:CB82582892
- 分子式:C31H32N4O6
- 分子量:556.61
- MOL File:232931-57-6.mol
- 沸点 :805.5±65.0 °C(Predicted)
- 密度 :1.36±0.1 g/cm3(Predicted)
- 储存条件 :Sealed in dry,Room Temperature
- 溶解度 :DMSO: ≥ 100 mg/mL (179.66 mM)
- 酸度系数(pKa) :3.88±0.20(Predicted)
- 形态 :Solid
- 颜色 :Off-white to yellow
SJG 136性质、用途与生产工艺
- 生物活性 SJG-136 是一种有效的 DNA 交联剂 (DNA crosslinker),与 pBR322 DNA 交联的 XL50 值为 45 nM。SJG-136 具有抗肿瘤作用。
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靶点
XL50: 45 nM (pBR322 DNA)
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体外研究
SJG-136 (dimer 5) is a DNA cross-linking agent, with an XL 50 (concentration of agent required for 50% cross-linking of pBR322 DNA) of 45 nM for pBR322 DNA. SJG-136 is cytotoxic to ovarian cell lines, such as A2780 (IC 50 , 22.5 pM), A2780cisR (IC 50 , 24 pM), CH1 (IC 50 , 0.12 nM), CH1cisR (IC 50 , 0.6 nM), and SKOV-3 (IC 50 , 9.1 nM). SJG-136 (SG2000) also reduces the viability of a panel of canine cancer cells, with GI 50 values ranging from 0.33 - >100 nM after a 1 h exposure, and <0.03 - 17.33 nM following continuous exposure.
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体内研究
SJG-136 shows more potent antitumor effect against CMeC-1 tumour at 0.30 mg/kg than 0.15 mg/kg either as a single dose or administered once a week for three weeks via dosed intravenously in mice. SJG-136-induced H2AX phosphorylation shows good correspondence, but less sensitivity, than measurement of foci.
- 更新日期:2024/11/08
- 产品编号:HY-14573
- 产品名称:SJG 136 SJG-136
- CAS编号:232931-57-6
- 包装:1 mg
- 价格:2800元
- 更新日期:2024/11/08
- 产品编号:HY-14573
- 产品名称:SJG 136 SJG-136
- CAS编号:232931-57-6
- 包装:5mg
- 价格:4900元
- 公司名称:BOC Sciences
- 联系电话: 16314854226
- 电子邮件:info@bocsci.com
- 国家:美国
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- 公司名称:Musechem
- 联系电话:+1-800-259-7612
- 电子邮件:info@musechem.com
- 国家:美国
- 产品数:4660
- 优势度:60
- 公司名称:TargetMol Chemicals Inc.
- 联系电话:+1-781-999-5354 +1-00000000000
- 电子邮件:marketing@targetmol.com
- 国家:美国
- 产品数:32161
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- 公司名称:Cckinase, Inc.
- 联系电话:+1 (732)236-3202
- 电子邮件:sales@cckinase.com
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- 公司名称:MedChemExpress
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- 公司名称:International Laboratory Limited
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- 电子邮件:admin@intlab.org
- 国家:美国
- 产品数:5356
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