6-[4-(叔丁基)苯氧基]吡啶-3-胺

生物活性靶点体外研究体内研究 6-[4-(叔丁基)苯氧基]吡啶-3-胺试剂级价格

CAS号:218457-67-1
英文名:5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
中文名:6-[4-(叔丁基)苯氧基]吡啶-3-胺
CBNumber:CB8254830
分子式:C15H18N2O
分子量:242.32
MOL File:218457-67-1.mol

6-[4-(叔丁基)苯氧基]吡啶-3-胺化学性质

熔点 :89-90
储存条件 :2-8°C
溶解度 :Soluble in DMSO (>30 mg/ml)
形态 :solid
颜色 :Off-white to pale orange
稳定性 :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS 数据库 :218457-67-1(CAS DataBase Reference)

安全信息

危险品标志 :Xi
Hazard Note :Irritant
海关编码 :2933399990

6-[4-(叔丁基)苯氧基]吡啶-3-胺性质、用途与生产工艺

生物活性 CB-103 是一种口服活性的 Notch 转录激活复合物的抑制剂。CB-103 可在果蝇和小鼠中产生Notch功能丧失的表型，并抑制人类乳腺癌和白血病异种移植瘤的生长。
靶点
Target Value
Notch
()

体外研究

CB-103 acts as a pan-NOTCH inhibitor by targeting NOTCH transcriptional activation complex.
CB-103 has shown the ability to block NOTCH signaling in human T cell acute lymphoblastic leukemia cancer cell lines.
CB-103 exhibits anti-tumor efficacy in GSI resistant T-ALL cell lines.

Cell Viability Assay

Cell Line:	RPMI 8402, KOPTK1, PANC1, nRas driven melanoma cells
Concentration:	10 μM
Incubation Time:	4 days, 6 days
Result:	Caused a significant reduction in their growth potential.

体内研究

CB-103 inhibits NOTCH dependent cellular processes in mice.
CB-103 blocks in vivo growth of PDX models of T-ALL.
CB-103 (25 mg/kg; i.p./p.o.; 2x daily; for 2 weeks) inhibits growth of GSI/Mab resistant triple negative breast cancer.
CB-103 exhibits anti-tumor activity in xenograft models of human T-ALL and mouse mammary tumors.

Animal Model:	NSG mice, triple negative breast cancer mouse xenograft model
Dosage:	25 mg/kg
Administration:	Oral administration/Intraperitoneal injection; 2x daily; for 2 weeks
Result:	Inhibited growth of GSI/Mab resistant triple negative breast cancer.