ChemicalBook CAS数据库列表 5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮
5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮
![5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮,900515-16-4,结构式](https://www.chemicalbook.com/CAS/GIF/900515-16-4.gif)
- CAS号:900515-16-4
- 英文名:5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
- 中文名:5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮
- CBNumber:CB82093286
- 分子式:C14H8FNO4S
- 分子量:305.28
- MOL File:900515-16-4.mol
5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮化学性质
- 熔点 :>235oC (dec.)
- 密度 :1.559±0.06 g/cm3(Predicted)
- 储存条件 :2-8°C
- 溶解度 :DMSO: >20mg/mL
- 酸度系数(pKa) :7.20±0.20(Predicted)
- 形态 :solid
- 颜色 :yellow
安全信息
- WGK Germany :3
5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮性质、用途与生产工艺
- 生物活性 AS-252424是一种新型，有效的PI3Kγ抑制剂，IC50为30 nM，作用于PI3Kγ比作用于PI3Kα选择性高30倍，对PI3Kδ/β具有低的抑制活性。
- 体外研究 AS-252424 is a furan-2-ylmethylene thiazolidinedione as a selective ATP-competitive PI3Kγ inhibitor with IC50 with 33 nM. AS-252424 shows reduced potency on PI3Kα with an IC50 with 935 nM. When screening against 80 different Ser/Thr and Tyr kinases, AS-252424 doesn't show significant inhibit towards any of them at 10 μM except for CK2. AS-252424 inhibits C5a-mediated PKB/Akt phosphorylation in a concentration- dependent manner with submicromolar or low-micromolar IC50 value. AS-252424 inhibits MCP-1-mediated chemotaxis in wild-type primary monocytes in a concentration-dependent manner with an IC50 value of 52 μM, as well as in the monocytic cell line THP-1 with an IC50 value of 53 μM. AS252424 specifically blocks proliferation in the pancreatic cancer cell lines HPAF and Capan1, as assessed by cell counting. A recent research indicates 100 nM of AS-252424 significantly reduces [Ca2+]i, ICa and Ca2+ transients in HL-1 cardiomyocytes.
- 体内研究 Oral administration of AS-252424 at 10 mg/kg results in moderate reduction of neutrophil recruitment (35%), almost matching the result observed in PI3Kγ-deficient mice.
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靶点
PI3Kα
935 nM (IC 50 )
PI3Kγ
30 nM (IC 50 )
PI3Kδ
20 μM (IC 50 )
PI3Kβ
20 μM (IC 50 )
5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮上下游产品信息
上游原料
下游产品
5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-13532
- 产品名称：AS-252424
- CAS编号：
- 包装：1 mg
- 价格：350元
- 更新日期：2024/11/08
- 产品编号：HY-13532
- 产品名称：5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮 AS-252424
- CAS编号：900515-16-4
- 包装：5mg
- 价格：770元
5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮生产厂家
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
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