周效磺胺

简介用途生物活性体外研究周效磺胺试剂级价格

周效磺胺

CAS号:2447-57-6
英文名:Sulfadoxine
中文名:周效磺胺
CBNumber:CB8171942
分子式:C12H14N4O4S
分子量:310.33
MOL File:2447-57-6.mol

周效磺胺化学性质

熔点 :190-194°C
沸点 :298°C (rough estimate)
密度 :1.4006 (rough estimate)
折射率 :1.6270 (estimate)
储存条件 :Keep in dark place,Inert atmosphere,Room temperature
溶解度 :Soluble in ethanol & ammonium hydroxide (9:1) at 20mg/ml
形态 :powder
酸度系数(pKa) :6.16±0.50(Predicted)
颜色 :white
水溶解性 :209.8mg/L(temperature not stated)
Merck :14,8906
BRN :625453
BCS Class :3/1

安全信息

危险品标志 :Xi
危险类别码 :36/37/38
安全说明 :26
WGK Germany :2
RTECS号 :DA9500000
海关编码 :29350090
毒性 :LD50 in mice (microcrystals, mg/kg): 5200 orally, 2900 s.c., 2900 i.p. (Bhni)

周效磺胺 MSDS

Sulformethoxine

周效磺胺性质、用途与生产工艺

简介
周效磺胺别名周效磺胺，磺胺多辛，磺胺邻二甲氧嘧啶。其是一种白色或类白色结晶粉末。其主要用于气管炎、肺炎、菌痢、尿路感染、皮肤软组织感染及预防风湿热等。
用途周效磺胺一般用于炎症的治疗，如上呼吸道感染扁桃体炎、菌痢肠炎、皮肤感染等，还可与其他药物配合，用于治疗肺结核、淋巴结核。
生物活性 Sulfadoxine (Sulphadoxine) 是一种超长效磺胺类药物，作用于P. Vivax，IC50为249 μg/ml。
体外研究

Sulfadoxine(Sulphadoxine) is an ultra-long-lasting sulfonamide. Sulfadoxine is often used in combination with pyrimethamine to treat or prevent malaria. Both drugs are antifolates; they inhibit the production of enzymes involved in the synthesis of folic acid within the parasites. Either drug by itself is only moderately effective in treating malaria, because the parasite Plasmodium falciparum may be able to use exogenous folic acid, i.e. folic acid which is present in the parasite's environment, while in combination, the two substances have a synergistic effect which outbalances that ability [1, 2].
用途超长效类磺胺药物，用于治疗脑膜炎、尿路感染等
类别有毒物品
毒性分级中毒
急性毒性口服-小鼠LD50: 5200 毫克/公斤; 腹腔-小鼠LD50: 2900 毫克/公斤
可燃性危险特性可燃;燃烧产生有毒氮氧化物和硫氧化物烟雾
储运特性库房通风低温干燥
灭火剂干粉、泡沫、砂土、二氧化碳, 雾状水