273727-89-2
- CAS号:273727-89-2
- 英文名:1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-
- 中文名:273727-89-2
- CBNumber:CB81216044
- 分子式:C23H25NO
- 分子量:331.45
- MOL File:273727-89-2.mol
- 沸点 :478.8±28.0 °C(Predicted)
- 密度 :1.083±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :Soluble in DMSO
- 酸度系数(pKa) :7.99±0.50(Predicted)
273727-89-2性质、用途与生产工艺
- 生物活性 ZM39923 是一种 JAK3 抑制剂， pIC50 值为 7.1；ZM39923 同时可抑制组织型转谷氨酞胺酶 (TGM2) 的活性，IC50 值为 10 nM。
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靶点
JAK3
7.1 (pIC 50 )
JAK1
4.4 (pIC 50 )
EGF-R
5.6 (pIC 50 )
Lck
5.0 (pIC 50 )
CDK4
5.0 (pIC 50 )
TGM2
10 nM (IC 50 )
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体外研究
ZM39923 is a JAK3 inhibitor, with a pIC 50 of 7.1. ZM39923 (Compound 7) shows weak inhibitory effect on EGF-R and JAK1 (pIC 50 , 5.6, 4.4, respectively), and insignificantly inhibits tyrosine kinases Lck and CDK4 (pIC 50 <5.0). ZM39923 potently inhibits tissue transglutaminase (TGM2) with an IC 50 of 10 nM, and acts directly on purified TGM2 to inhibit the Ca 2+ activated form of TGM2. ZM39923 blocks the phosphorylation of JAK3 induced by CCL19, and such an effect is similar to that of CCR7 antibody. ZM39923 also significantly blocks the CCL19 induced wound closure rate, and decreases the migration and invasion of PCI-37B cells.
- 公司名称：SYNCHEM-OHG
- 联系电话：+49 5662 408730
- 电子邮件：info@synchem.de
- 国家：德国
- 产品数：4705
- 优势度：70
