Vasonatrin Peptide (VNP)
- CAS号:141676-35-9
- 英文名:Vasonatrin Peptide (VNP)
- 中文名:Vasonatrin Peptide (VNP)
- CBNumber:CB7998982
- 分子式:C124H198N36O36S3
- 分子量:2865.34
- MOL File:141676-35-9.mol
- 密度 :1.47±0.1 g/cm3(Predicted)
Vasonatrin Peptide (VNP) 性质、用途与生产工艺
- 生物活性 Vasonatrin peptide (VNP) 是心房钠尿肽 (ANP) 和C型利尿钠肽 (CNP) 的嵌合体,具有高效的静脉扩张和利钠活性。
-
靶点
Natriuretic peptide receptors
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体外研究
Vasonatrin peptide binds with both natriuretic peptide receptor A and B, but with a preference for B. VNP-stimulated cGMP is 11-fold greater in NPRB than NPRA.
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体内研究
The high-fat diet-fed streptozotocin-induced diabetic Sprague-Dawley rats are subjected to ischemia-reperfusion operation. VNP treatment (100 g/kg iv, 10 min before reperfusion) significantly improved the instantaneous first derivation of left ventricle pressure (LV dP/dtmax) and LV systolic pressure and reduced LV end-diastolic pressure, apoptosis index, caspase-3 activity, plasma creatine kinase (CK), and lactate dehydrogenase (LDH) activities. Treatment hypoxia-induced pulmonary hypertension (HPH) with Vasonatrin peptide for 1 week significantly reduceS mean pulmonary arterial pressure, pulmonary vascular resistance, RVH and muscularization of the pulmonary arteries. Acute intravenous administration of 50 microg/kg Vasonatrin peptide significantly ameliorates pulmonary haemodynamics in HPH rats.
- 更新日期:2023/03/20
- 产品编号:HY-P1556
- 产品名称:Vasonatrin Peptide (VNP) Vasonatrin Peptide (VNP)
- CAS编号:141676-35-9
- 包装:500μg
- 价格:2000元
- 更新日期:2023/03/20
- 产品编号:HY-P1556
- 产品名称:Vasonatrin Peptide (VNP) Vasonatrin Peptide (VNP)
- CAS编号:141676-35-9
- 包装:1mg
- 价格:3600元
- 公司名称:Creative Peptides
- 联系电话:
- 电子邮件:info@creative-peptides.com
- 国家:美国
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