马来酸甲硫替平
- CAS号:74611-28-2
- 英文名:METHIOTHEPIN MESYLATE SEROTININ 5-HT(1) ANT
- 中文名:马来酸甲硫替平
- CBNumber:CB7972919
- 分子式:C20H24N2S2CH3SO3H
- 分子量:0
- MOL File:74611-28-2.mol
- 储存条件 :Store at -20°C
- 溶解度 :H2O: soluble13mg/mL
- 形态 :solid
- 颜色 :white
- WGK Germany :3
马来酸甲硫替平性质、用途与生产工艺
- 生物活性 Methiothepin mesylate 是一种有效的,非选择性的 5-HT2 receptor 拮抗剂,pKd 值为 7.10 (5-HT1A),7.28 (5HT1B),7.56 (5HT1C),6.99 (5HT1D),7.0 (5-HT5A),7.8 (5-HT5B),8.74 (5-HT6) 和 8.99 (5-HT7),pKi 值为 8.50 (5HT2A),8.68 (5HT2B) 和 8.35 (5HT2C)。
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靶点
5-HT 1A Receptor
7.10 (pKd)
5-HT 1B Receptor
7.28 (pKd)
5-HT 1C Receptor
7.56 (pKd)
5-HT 1D Receptor
6.99 (pKd)
5-HT 5A Receptor
7.0 (pKd)
5-HT 5B Receptor
7.8 (pKd)
5-HT 6 Receptor
8.74 (pKd)
5-HT 7 Receptor
8.99 (pKd)
5-HT 2A Receptor
8.50 (pKi)
5-HT 2B Receptor
8.68 (pKi)
5-HT 2C Receptor
8.35 (pKi)
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体外研究
Methiothepin mesylate is a 5-HT receptor antagonist, with pK d s of 7.10, 7.28, 7.56, and 6.99 for 5-HT 1A , 5HT 1B , 5HT 1C , 5HT 1D . Methiothepin mesylate also shows pK d s of 7.0, 7.8, 8.74, and 8.99 for 5-HT 5A , 5-HT 5B , 5-HT 6 , and 5-HT 7 , respectively. Methiothepin exhibits high affinity at 5-HT 2A , 5HT 2B , and 5HT 2C with pK i s of 8.50, 8.68, and 8.35, respectively.
- 公司名称:SIGMA
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- 国家:瑞士
- 产品数:6913
- 优势度:91